Institut National De La Sante Et De La Recherche Medicale

Institut Pasteur De Lille

Institut Pasteur

UniversitÉ Libre De Bruxelles

Institute Pasteur De Lille

Universite Du Droit Et De La Sante De Lille Ii

Universite Du Droit Et De La Sante - Lille Ii

Christian Sergheraert

Andre Tartar

Helene Gras-Masse

Elisabeth Gomard

Remy Magne

Frederic Martinon

Christophe Boutillon

Jean-Paul Levy

Camille Locht

Françoise Mascart

Stéphane Temmerman

Jean-Michel Hougardy

Sammy Place

The present invention concerns methods for in vitro detection of an infection byin mammals, and methods for in vitro distinction between mammals infected within which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected byor presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected byor presenting a latent form of tuberculosis.

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Cytotoxic lymphocyte-inducing lipopeptides comprising a peptide part having between 10 and 40 amino acids approximately and comprising at least one tigenic determinant. The lipopeptides also comprise one or more chains derived from fatty acids and one or more modified steroid groups. Said lipopeptides may be used for immunizing the human or animal body against pathogenic agents such as viruses or parasites. The peptide part may, in particular, be a fragment of the protein encoded by the ENV gene, by the NEF gene or by the GAG gene of HIV viruses.

Cytotoxic T lymphocyte-inducing lipopeptides and use as vaccines

Cytotoxic lymphocyte-inducing lipopeptides comprising a peptide fragment having approximately between 10 and 40 amino acids and comprising at least one antigenic determinant and also comprising one or more chains derived from fatty acids and one or more modified steroid groups useful for immunizing a human or animal body against pathogenic agents such as viruses or parasites which fragment is preferably a fragment of the protein encoded by the ENV gene, by the NEF gene or by the GAG gene of HIV viruses.

Cytotoxic T lymphocyte-inducing lipopeptides and methods of use

Cytotoxic lymphocyte-inducing lipopeptides comprising a peptide part having between 10 and 40 amino acids approximately and comprising at least one antigenic determinant. The lipopeptides also comprise one or more chains derived from fatty acids and one or more modified steroid groups. Said lipopeptides may be used for immunizing the human or animal body against pathogenic agents such as viruses or parasites. The peptide part may, in particular, be a fragment of the protein encoded by the ENV gene, by the NEF gene or by the GAG gene of HIV viruses. DA.

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Morbecque, France

Christian Sergheraert