Institut Curie

Centre National De La Recherche Scientifique

Agence Nationale De Valorisation De La Recherche (anvar)

Commissariat a L'energie Atomique Et Aux Energies Alternatives

Universitè De Montpellier

Agence Nationale De Valorisation De La Recherche

Université Paris Sud-paris Xi

The University of Montpellier 2 Science and Techniques

Université Montpellier 2 Sciences Et Techniques

Christian Rivalle

Emile R Bisagni

Luc Montagnier

Jean-Claude Chermann

Pierre Tambourin

Francoise Wendling

Claire Ducrocq

Jamal Tazi

David Grierson

Jacqueline Gruest

Florence Mahuteau-Betzer

Caroline Barette

Fabrice Lejeune

Chi Hung Nguyen

Renaud Prudent

Philippe Jeanteur

Johann Soret

ChiHung Nguyen

Emilie Vassal

Alain Civier

Rosette Lidereau

The present invention relates to a compound derived from indole corresponding to the following formula II: wherein X represents N, CR8 or NR8, wherein R8 represents a hydrogen atom, a hydroxyl or alkyl or methoxy group optionally substituted with a phenyl group; R2, R3 and R4 independently represent a hydrogen atom or a halogen atom or an optionally substituted alkyl, amine, alkene, ester, sulfonamide, ether or benzyl group; R5 represents a hydrogen atom or an optionally substituted, saturated or unsaturated alkyl group, amine, benzyl group; R6 represents an optionally substituted C1-C3 alkyl group; R7 represents a hydrogen atom or an optionally substituted C1-C3 alkyl group and R7 is absent when the ring A is in the b position, and A represents a ring; R9 and R10 represent together a carbon bond or independently represent an R11 OR11, SR11 group; wherein R11 represents a hydrogen atom, an optionally substituted, saturated or unsaturated, C1-C3 alkyl group, which may contain one or more sulfur, oxygen or nitrogen atoms; pharmaceutically acceptable salts of said compounds, their isomers and/or a mixture thereof; pharmaceutical composition comprising such a compound; the use of such a compound for preparing a drug intended to treat a genetic disease resulting from at least one mutation causing the occurrence of an early termination codon.

Compounds derived from indole and pharmaceutical compositions containing them

Pyridocarbazole-type compounds of formula (I): are provided as a medicament, and more particularly for application in anticancer chemotherapy. Also provided is a pharmaceutical composition with the compound and methods for preventing and/or treating neurodegenerative-type pathologies, such as Alzheimer's disease and schizophrenia, parasitoses, such as malaria, or glaucomas.

Pyridocarbazole type compounds and applications thereof

The invention relates to indole-derived compounds and to the use of said compounds for the preparation of a medicament that can be used to treat diseases related to the process of splicing pre-messenger RNAs in the cell, such as Frasier syndrome, frontotemporal dementia linked to chromosome 17 (a form of Parkinson's disease), Leigh syndrome (a type of encephalopathy), atypical cystic fibrosis, certain neuropathologies including Alzheimer's disease linked to a mutation in the Tau protein, muscle atorphy which affects the SMN (Survival of Motor Neuron) gene, depression linked to a serotonin splicing impairment, and certain cancers in which the global splicing process is affected (e.g. breast cancer, colon cancer and certain lymphomas), as well as viral diseases such as AIDS.

Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process

The invention relates to compounds of formula: ##STR1## wherein R'.sub.1 =H, OH or an alkyl group, preferably a lower alkyl group, alkylthio or alkoxy, an halogen or an amino group,

Dipyrido (4,3-B) (3,4-F) indoles, process for obtaining them,

The novel derivatives correspond to the general formula: ##STR1## in which R.sub.1 is a Y--(CH.sub.2).sub.n --NR.sub.4 R.sub.5 group, where Y represents a single bond or the group ##STR2## R.sub.4 and R.sub.5, identical or different, are hydrogen or an alkyl radical, preferably a lower alkyl, or again form together a ring which can include heteroatoms, in particular nitrogen atoms. n is a number ranging from 1 to 10, notably from 2 to 7, R.sub.2 is a hydrogen atom, a lower alkyl group or an aralkyl group in which the alkyl substituent is a lower alkyl group, and R.sub.3 is a hydrogen atom or a CH.sub.3 group useful for the treatment of leukemias.

Pyrido (4,3-B) carbazoles substituted in the 1 position by a polyamine

Dipyrido [4,3-b] [3,4-f] indoles and process for obtaining them

Growing community of inventors

Paris, France

Christian Rivalle