Other

Marina Biotech, Inc.

Biontech Delivery Technologies Gmbh

Christian Reinsch

Steffen Panzner

Volkmar Wendisch

Christina Dreher

Silke Lutz

Evgenios Siepi

Claudia Müller

The invention provides polyamine derivatives, a use of the polyamine derivatives for the transfection of polyanions into cells, and a method of transfecting cells with a polyanion, comprising mixing said polyanion with a polyamine derivative e.g. in a buffer and treating said cells with the mixture obtained in the previous step.

Carboxylated polyamine derivatives as transfection reagents

The invention provides hydroxylated polyamine derivatives, their use for the transfection of polyanions into cells, and a method of transfecting cells with a polyanion, comprising mixing said polyanion with said hydroxylated polyamine derivative in a buffer and treating said cells with the mixture obtained in the previous step.

Hydroxylated polyamine derivatives as transfection reagents

Lipid assemblies, such as liposomes, comprising transfection enhancer elements (TEE's), which are complexed with the lipid assemblies by means of ionic interactions, or lipids incorporating such TEE's are disclosed for enhancing the fusogenicity of the lipid assemblies. The TEE's have the formula:hydrophobic moiety-pH sensitive hydrophilic moiety&#x2003;&#x2003;(II)The pH sensitive hydrophilic moiety of each TEE is a weak acid having a pka of between 2 and 6 or a zwitterionic structure comprising a combination of acidic groups with weak bases having a pKa of between 3 and 8. Lipids incorporating one or more such TEEs have the formula (I):Lipid moiety-[Hydrophobic moiety-pH sensitive hydrophilic moiety]&#x2003;&#x2003;(I).

Lipids and lipid assemblies comprising transfection enhancer elements

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Halle, Germany

Christian Reinsch