Amgen Inc.

Novo Nordisk A/s

Christian Plambech

Matias Melander

Jesper Peter Windum

Bjarke Lykke Ludvig Svendsen

Dylan Bourelle

Joshua Jay Dudman

Jakob Halkjaer Pedersen

Michael Sorensen

Adam B McCullough

Bo Radmer

Christian Hoejris Nielsen

Rasmus Øhlenschlæger

Emil Gram Spork

Tom Hede Markussen

Brian Stonecipher

Lars Peter Klitmose

Ronald Forster

Emil Wegger Jensen

Joseph Michael Iglesias

Margaux Frances Boyaval

Morten Sørensen

Claus Jepsen

John Oestergaard Madsen

Lars Stenholt

Ryan Jerome Ramos

Hans Stenberg Knudsen

Soeren Dyring Jensen

Jørgen Jørgensen

Lars Eilertsen

Simon Munch Pedersen

Julian Jazayeri

Ebbe Kiilerich

Bo Kvolsbjerg

Morten Soerensen

Bjoern Gullak Larsen

Avon Kuo

Ruben Archilla

Mattias Ingerslev

Bjarke Lykke Ludvig Hooge

Rasmus Øhlenschlaeger

Søren Dyring Jensen

Kalle Holck Madsen

Knud Skifter Winther

John ØStergaard Madsen

Rasmus ØHLENSCHLÆGER

Morten SØRENSEN

Christian Højris Nielsen

Handheld drug delivery device

An injector includes a housing having a syringe assembly and an actuating mechanism at least partially disposed within the housing. The syringe assembly includes a syringe barrel that stores a medicament to be injected into a user, a needle assembly, and a filter member disposed adjacent to the needle assembly. The actuating mechanism is operatively coupled to the syringe assembly and includes a torque spring that exerts a torque to urge the medicament through the filter member to be injected into the user. The actuating mechanism further includes a damper mechanism that exerts an opposing force to dampen the motion exerted by the torque spring.

Torque driven drug delivery device

A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.

Drug delivery device

Injection systems for drug delivery are disclosed. A system may include a container filled or fillable with a drug, a stopper movably disposed in the container, a plunger, an energy source outputting a force, a mechanical linkage operable to transmit the force output by the energy source to the plunger to cause the plunger to act on the stopper to expel the drug from the container, and a trigger member. The system may have pre-injection state where the trigger member inhibits actuation of the mechanical linkage, an injection state where the trigger member permits actuation of the mechanical linkage, and a post-injection state where the plunger is stationarily positioned in an end-of-dose position. The system may be designed to limit the number of components included in various force transmission loops present in the pre-injection, injection, and/or post-injection states.

Injection systems for drug delivery with internal force transmission

Drug delivery devices and related arrangements are disclosed. A drug delivery device may include a housing having an opening, a drug storage container including a delivery member with an insertion end configured to extend at least partially through the opening, and a plunger. A drive mechanism may be included for driving the plunger in a distal direction to expel a drug from the drug storage container through the delivery member upon activation. The drug delivery device may additionally include a guard moveably disposed adjacent to the opening and operably coupled to the drive mechanism for activation of the drive mechanism. A lock may be selectively engageable with the guard to limit movement of the guard in the proximal direction. An indicator may be coupled to the drive mechanism to generate an audible signal during drug delivery, and to cease generating the audible signal when drug delivery is complete.

A drug delivery device includes a housing defining a shell having a proximal and a distal end, a needle assembly at least partially disposed within the housing at the proximal end, a drive assembly at least partially disposed within the housing, and a damper mechanism at least partially disposed within the housing adjacent to the distal end. The housing further defines a longitudinal axis extending between the proximal end and the distal end. The needle assembly includes a syringe barrel containing a medicament and a needle or a cannula. The drive assembly is operably coupled to the needle assembly to urge the medicament through the needle or cannula. The damper mechanism is operably coupled to the drive assembly and the housing. Upon activating the drive assembly, the damper mechanism dampens an effect thereof.

Drug delivery device having damping mechanism

A drug delivery device comprises a housing () and an expelling assembly with a piston rod (), a drive tube () with an outer surface and a scale drum () arranged between the drive tube and the housing, the scale drum being coupled to the housing and the drive tube outer surface. The device further comprises a drive spring () arranged between the housing and the drive tube, and setting means () allowing a user to simultaneously set a dose amount to be expelled and strain the drive spring correspondingly by rotation of the drive tube. The scale drum is coupled to the drive tube via a spline connection, wherein the drive spring is arranged proximally of the spline connection when the spline connection is in its proximal-most position.

Drug delivery device with slim drive mechanism

A drug delivery device comprising a rotatable scale drum, a trigger member, an actuation member, a trigger spring acting on the trigger member and being energized by movement of the actuation member, as well as an end-of-dose switch adapted to be actuated by movement of the trigger member. The trigger member is adapted to be arranged in an axially supported position against the action of the energized trigger spring, and released from the axially supported position when the scale drum is rotated from a set position to an end-of-dose position, whereby the trigger member is moved axially by the trigger spring, the end-of-dose switch thereby being actuated.

Drug delivery device with end-of-dose trigger arrangement

A portable pen-type drug injection device () comprises a main portion () and a clip (). The clip comprises a base portion mounted to a portion of the drug delivery device, and a clip gripping portion with a free end. The device further comprises drug expelling means having dose setting means () allowing a user to set a dose of drug to be expelled, and a piston rod adapted to move a piston of a loaded cartridge in a distal direction to thereby expel drug from the cartridge. Electronic circuitry comprises sensor means adapted to detect a set and/or an expelled dose, and a display () is provided to display dose-related values, wherein at least a portion of the display is arranged in the flexible clip main portion.

Pen-type drug delivery device with electronic display on clip member

Growing community of inventors

Soeborg, Denmark

Christian Plambech