Universitat Fur Bodenkultur Wien

St. Anna Kinderkrebsforschung

Christian Obinger

Michael Traxlmayr

Charlotte Brey

Manfred Lehner

A ligand regulated protein-protein interaction system based on a lipocalin-fold molecule including: (a) a lipocalin-fold molecule; (b) a lipocalin-fold ligand with a low molecular weight of 1500 Da or below; and (c) a lipocalin-fold binding interaction partner, wherein the lipocalin-fold molecule can bind to the lipocalin-fold ligand; and wherein the lipocalin-fold molecule bound to the lipocalin-fold ligand binds to the lipocalin-fold binding interaction partner with an affinity which is at least 10-fold higher than the affinity of the lipocalin-fold molecule not bound to the lipocalin-fold ligand; and wherein the lipocalin-fold binding interaction partner is not a naturally occurring protein which has an affinity of <10 μM to any naturally occurring lipocalin-fold molecule in the presence of any lipocalin-fold ligand.

Ligand regulated protein-protein interaction system

A ligand regulated protein-protein interaction system based on a lipocalin-fold molecule including:

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Vienna, Austria

Christian Obinger