Abiomed, Inc.

Massachusetts Institute of Technology

The Brigham and Women's Hospital, Inc.

Christian Moyer

Ahmad El Katerji

Scott C Corbett

David M Weber

Elazer Reuven Edelman

Steven F Keller

Noam Josephy

Brian Yale Chang

Qing Tan

Alexander Ship

Sonya Sanat Bhavsar

Rebecca D'Agostine

Tim Preskenis

Erik Kroeker

Steven Keller

Display panel or portion thereof with graphical user interface

The systems, devices, and methods presented herein use a blood pump to obtain measurements of cardiac function. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as aortic pressure or motor current, then calculate and display one or more cardiac parameters and heart function parameters, such as left ventricular pressure, left ventricular end diastolic pressure, or cardiac power output. These parameters provide valuable information to a user regarding current cardiac function, as well as positioning and function of the blood pump. In some embodiments, the system can act as a diagnostic and therapeutic tool. Providing cardiac parameters in real-time, along with warnings about adverse effects and recommendations to support cardiac function, such as increasing or decreasing the volumetric flow rate of blood pumped by the device, administering pharmaceutical therapies, and/or repositioning the blood pump allow clinicians to better support and treat cardiovascular disease.

Determination of cardiac parameters for modulation of blood pump support

The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

Systems and methods for determining cardiac performance

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Danvers, MA, United States of America

Christian Moyer