North Carolina State University

The Ohio State University

Christian Melander

Robert W Huigens, Iii

Steven Andrew Rogers

Justin J Richards

John Cavanagh

T Eric Ballard

Catherine S Reed

David F Ritchie

Zhaoming Su

Jonathan S Lindsey

Thomas W Lindsey

Lingling Peng

Roberta Melander

W Steve McCall

Cynthia Bunders

Laura Kuo

William M Huggins

David Kendall Jung

Samuel Onofre Reyes

Eric T Ballard

Robert W Iii Huigens

In one aspect, the disclosure relates to compositions and methods for dispersing exitingbiofilms and inhibiting formation ofbiofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistentinfection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Substituted 2-aminobenzimidazoles analogs as antibiofilm agents

Provided are 2-aminoimidazole-phenyl derivative compounds of Formula (I): which compounds are useful in methods of controlling microbial growth, such as by enhancing the effects of an antibiotic administered in combination with the compound. Compositions including these compounds, devices including these compounds, and methods of using the same are also provided. 

2-aminoimidazole-phenyl derivatives useful for controlling microbial growth

Disclosure is provided for imidazole-phenyl derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.

Inhibition of bacterial biofilms with imidazole-phenyl derivatives

Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an aryl carbamate as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an aryl carbamate compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or a plant defense activator.

Use of aryl carbamates in agriculture and other plant-related areas

Disclosure is provided for imidazole derivative compounds useful to inhibit the formation of biofilms and/or inhibit microbial growth, compositions including these compounds, devices including these compounds, and methods of using the same.

Inhibition of bacterial biofilms and microbial growth with imidazole derivatives

Disclosure is provided for 1,4,5-substituted amino imidazole compounds useful to control microbial growth, compositions including these compounds, devices including these compounds, and methods of using the same.

Imidazole derivatives useful for controlling microbial growth

Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an active compound as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an active compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or plant defense activator.

Inhibition and dispersion of biofilms in plants with imidazole-triazole derivatives

Disclosure is provided for benzimidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same.

Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives

Disclosure is provided for imidazole-triazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.

Inhibition and dispersion of bacterial biofilms with imidazole-triazole derivatives

Disclosure is provided for imidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.

Growing community of inventors

Raleigh, NC, United States of America

Christian Melander