Janssen Biotech, Inc.

Christian Martinez

Ellen Chi

Ronald Swanson

Jinquan Luo

Chichi Huang

Galina Obmolova

Jarrat Jordan

Xiefan Lin-Schmidt

Judith Ann Connor

Lu Lu

Sheng-Jiun Wu

Alexey Teplyakov

Juan C Almagro

Gopalan Raghunathan

Hong Mimi Zhou

Glenn Mark Anderson

Kam-Fai Tse

Wilson Edwards

Ann Lacombe

Matt Husovsky

H Mimi Zhou

Juan Carlos Almagro

Sheng-Jium Wu

In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a GP5B83 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include GP5B83.

Anti-idiotypic antibodies against anti-GPRC5D antibodies

The present invention relates to antibodies that broady neutralize interferon-&#x3b1; and interferon-&#x3c9;, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.

Interferon alpha and omega antibody antagonists

Interferon &#x3b1; and &#x3c9; antibody antagonists

Broadly neutralizing interferon-&#x3b1; and interferon-&#x3c9; antibody antagonists, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are useful in the treatment of diseases associated with increased production of IFN&#x3b1; and IFN&#x3c9;.

The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.

Human tissue factor antibody and uses thereof

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San Diego, CA, United States of America

Christian Martinez