Synthelabo

Sanofi-aventis

Sanofi

Christian Maloizel

Mireille Sevrin

Pascal George

Yannick Evanno

Laurent Dubois

Benoit Marabout

Jean-Pierre Merly

Jacques Menin

Jacques Froissant

Juan Antonio Diaz Martin

André Malanda

Maria Dolores Jimenez Bargueno

Arlette Tixidre

Ulpiano Martin Escudero Perez

Manuel Bedoya Zurita

Gregorio Del Sol Moreno

Magali Romanach Ferrer

Odette Legalloudec

Jean Pierre Merly

Laurent DuBois

Denis Bigg

Compounds corresponding to the formula (I) as defined in the disclosure, as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the invention, and methods of treatment using them.

2H or 3H-benzo[E]indazol-1-YL carbamate derivatives, the preparation and therapeutic use thereof

2H- or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof

The invention relates to compounds of formula (I): Wherein X, X, X, X, Y and W are as described herein. The invention also relates to a preparation method and to a therapeutic application.

Derivatives of N-(heteroaryl)-1-heteroaryl-1H-indole-2-carboxamides, preparation thereof and therapeutic use thereof

Compounds corresponding to the formula (I) as defined in the disclosure as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the invention, and methods of treatment using them.

[object Object]

1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and

Pyrrole derivatives of formula: ##STR1## in which R.sub.1 represents a hydrogen or halogen atom, a linear or branched C.sub.1-6 alkyl group, a C.sub.3-6 alkenyl group, a C.sub.1-4 alkoxymethyl group, benzyl, a phenyl group optionally substituted by one or more halogen atoms or alkyl radicals, a CO.sub.2 R group in which R represents a linear or branched C.sub.1-4 alkyl radical, phenyl or benzyl, or a CONR'R' group in which R' and R' each represent, independently of one another, a hydrogen atom or a linear or branched C.sub.1-4 alkyl radical,

4H-thieno[3,4-c]pyrrole derivatives

A compound which is a carboxamide derivative of general formula (I) ##STR1## in which R represents a hydrogen atom, a methyl group or a phenoxyalkyl group of general formula ##STR2## in which X represents one or more substituents independently chosen from hydrogen, fluorine, chlorine, methyl, 1-methylethyl and methoxy and

2-piperidinylpyrimidine-4-carboxamide derivatives, and their use in

A compound which is a 2-aminopyrimidine carboxamide derivative represented by formula (I) ##STR1## in which X represents hydrogen, fluorine, chlorine, methyl, 1-methylethyl or methoxy, with the proviso that more than one substituent X may be present in which case each X may be the same or different,

2-aminopyrimidine-4-carboxamide derivatives, their preparation and their

A compound which is a 2-aminopyrimidine-4-carboxamide derivative, of the general formula (I) ##STR1## in which m is 0 or 1,

A compound of formula (I): ##STR1## in which: X is hydrogen or a methyl or methoxy group;

Derivatives of 2-((4-piperidinyl)methyl)-1,2,3,4-tetrahydroisoquinoline,

Derivatives of formula (I) ##STR1## in which X denotes a hydrogen or halogen atom, an alkoxy radical, an alkyl radical or an allyloxy radical, and R denotes a linear or branched alkyl radical, a cycloalkylalkyl radical, an alkenyl radical, an arylalkyl radical which can bear one or more substituents chosen from halogen atoms and methyl, methoxy and methylenedioxy radicals, or alternatively an optionally substituted phenyl radical, as well as the addition salts thereof with pharmaceutically acceptable acids produce an .alpha..sub.2 -receptor antagonist effect.

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Meudon, France

Christian Maloizel