Janssen Biotech, Inc.

Juno Therapeutics Gmbh

Fate Therapeutics, Inc.

Christian Maine

Daniel D Shoemaker

Ricardo Attar

Selina Khan

Manuel Sepulveda

Betsy Rezner

Eigen Peralta

David Robbins

Jonathan Rosen

Ian Hardy

Jason DeHart

Lucas James Thompson

Vinod Krishna

Barbara Sanders

Patrick Wilkinson

Jenifer Lum

Roland Zahn

Compounds that either produce a higher proportion or greater absolute number of phenotypically identified naive, stem cell memory, central memory T cells, adaptive NK cells, and type I NKT cells are identified. Compositions and methods for modulating immune cells including T, NK, and NKT cells for adoptive cell therapies, such as those providing improvements in one or more therapeutic outcomes, are provided.

Compositions and methods for immune cell modulation in adoptive immunotherapies

Provided are vaccines, polypeptides and polynucleotides based on mutant CALR and JAK2 sequences, vectors, host cells, viruses, and methods of making and using them. The disclosure also provides methods of inducing an immune response and methods of treating, preventing, reducing a risk of onset or delaying the onset of a clinical condition characterized by an expression of JAK2V617F or CALR exon 9 mutant, or both JAK2V617F and CALR exon 9 mutant, wherein the method comprises a plurality of administrations of any of the compositions comprising polynucleotides, polypeptides or vectors disclosed herein.

Vaccines based on mutant CALR and JAK2 and their uses

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San Diego, CA, United States of America

Christian Maine