Chanel Parfums Beaute

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

National Institute of Advanced Industrial Science and Technology

Institut Curie

Université De Lille

Christian Mahe

Gaelle Saintigny

Eleonora Candi

Renu Wadhwa

Sunil Kaul

Jean-Marie Aubry

Nobuhiro Ando

Raphaël Lebeuf

Lionel Larue

Maxime Nollet

Véronique Rataj-Nardello

Gerry Melino

Oriana Boucenna Verdier

Florian Rambow

Gennaro Melino

Gaëlle Saintigny

Disclosed is a microemulsion of oil-in-water type including, preferably consisting of, by weight relative to the total weight of microemulsion: &#x2022;70% to 94% of water, &#x2022;1% to 15% of at least one hydrophobic fragrancing substance, &#x2022;4% to 20% of at least one preferably volatile solvo-surfactant, and &#x2022;0.1% to 15%, preferably 1% to 13%, of at least one hydrotropic agent or at least one surfactant selected from anionic surfactants, cationic surfactants, amphoteric surfactants and non-ionic surfactants. The solvo-surfactant is selected from monoalkylated glycerol derivatives of following formula (I): wherein the 'alkyl' group is a linear or branched alkyl group including from 1 to 8 carbon atoms, and R and R' are each independently H or a linear or branched alkyl group including from 1 to 5 carbon atoms, with the proviso that R is different from R&#x2032;, and mixtures thereof.

Perfumes in the form of aqueous microemulsions

A method to identify target genes or proteins for regulating melanogenesis or pigmentation and to screen for compounds for manipulation of melanogenesis or pigmentation, the method of screening for candidate compounds for regulating melanogenesis or pigmentation, includes bringing test compounds into contact with cells capable of expressing mortalin and/or Hsp60 in vitro, and selecting, from among the test compounds, a compound that changes the expression level of mortalin and/or Hsp60.

Method of screening for candidate compounds for regulating melanogenesis or pigmentation

Identification and use of compounds which inhibit the expression or activity of micro-RNAs for preventing and/or attenuating ageing. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin including (a) bringing at least one test compound in contact with a sample of fibroblasts, (b) measuring the expression or the activity of at least one microRNA chosen from miR-134 and miR-152 in said fibroblasts, and (c) selecting the compounds for which an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the expression or an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the activity of at least one microRNA is measured in the fibroblasts treated in (a) compared with the untreated fibroblasts.

Inhibitors of micro-RNAs for use for preventing and/or attenuating skin ageing

At least one microRNA selected from among hsa-miR-330, hsa-miR-7 and hsa-miR-137, the mature forms thereof, and the precursors thereof, for depigmenting the skin, and an in vitro method for identifying depigmenting compounds, which includes the steps of: a) placing at least one test compound in contact with a sample of melanocytes; b) measuring the expression or activity of at least one microRNA selected from among miR-330, miR-7 and miR-137, the mature forms thereof, and the precursors thereof, in the melanocytes; c) selecting the compounds for which at least 20% activation of the expression or of the activity of at least one of the microRNAs is measured in the melanocytes treated in a) by an element for comparing with the untreated melanocytes.

Use of microrna molecules to influence skin pigmentation

Method of identifying and using compounds which inhibit the expression or activity of micro-RNAs for preventing and/or attenuating ageing, and/or for hydrating skin. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin, and/or for hydrating the skin, includes the following steps:

Inhibitors of micro-RNAs for use for preventing and/or attenuating skin ageing and/or for hydrating skin

Growing community of inventors

Neuilly sur Seine, France

Christian Mahe