Syngenta Participations Ag

Christian Lothschuetz

Tomas Smejkal

Helmars Smits

Miroslav Terinek

Jeremy Robert Godwin

Alexandre Christian Saint-Dizier

Peter Schneiter

Alexander Mark Heming

Wolfgang Stutz

The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein Ris C-Calkyl, C-Chaloalkyl, C-Ccycloalkyl, aryl or aryl substituted by one to five R, or aryl-C-Calkylene or aryl-C-Calkylene substituted by one to five R; andeach Ris independently C-Calkyl, C-Chaloalkyl, C-Calkoxy, C-Chaloalkoxy, cyano or halogen; The invention also relates to intermediates produced by the processes. Compounds of formula (I) are useful intermediates for the production of compounds in the agricultural and pharmaceutical fields.

Process for the preparation of substituted cycloserines

The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein Ris C-Calkyl, C-Chaloalkyl, C-Ccycloalkyl, aryl or aryl substituted by one to five R, or aryl-C-Calkylene or aryl-C-Calkylene substituted by one to five R; and each Ris independently C-Calkyl, C-Chaloalkyl, C-Calkoxy, C-Chaloalkoxy, cyano or halogen; The invention also relates to intermediates produced by the processes. Compounds of formula (I) are useful intermediates for the production of compounds in the agricultural and pharmaceutical fields.

The present invention relates to a composition and its use in a method for safening the phytotoxic effect of difenoconazole on a plant or plant propagation material. More specifically the composition comprises difenoconazole characterised in that least 40% by weight of said difenoconazole is the 2R, 4S isomer depicted as formula (Ib): and wherein at least 95% by weight of the remaining difenoconazole is the 2S, 4S isomer depicted as formula (Id): 

Difenoconazole sterepospmeric composition with reduced phytotoxicity

The present invention relates to a process for the preparation of a compound of formula (I), wherein X is &#x2014;CH&#x2014;, &#x2014;CH&#x2014;CH&#x2014;, &#x2014;CH&#x2014;CH&#x2014;CH&#x2014; or &#x2014;CH&#x2014;CH&#x2014;CH&#x2014;CH&#x2014;; Yis &#x2014;CH&#x2014;; &#x2014;CH&#x2014;CH&#x2014; or &#x2014;NH&#x2014;; Yis NHRor SH; wherein Ris hydrogen, C-Calkyl or phenyl; R-and R, independently from each other, represent aliphatic or aromatic groups; Rand R, independently from each other, represent aliphatic or aromatic groups; Rand Rare each hydrogen or represent together with the carbon atoms to which they are bonded, a phenyl ring; which process comprises reacting a compound of formula II [RuCI(R)n]m (II), wherein n is 1 and m is &#x3e;1 which represents a polymeric structure if Ris a molecule containing two alkene or alkyne moieties coordinating in an hapto-2 coordination mode to the metal; or n is 4 and m is 1 if Ris a nitrogen, oxygen or sulfur containing molecule in which said nitrogen, oxygen or sulfur coordinate to the metal; in the presence of an inert solvent which boiling point is from 1 12&#xb0; C. to 165&#xb0; C. with a compound of formula (III), wherein R, R, Yand Yare as defined under formula I, and a phosphane of formula IV RRP&#x2014;X&#x2014;PRR(iv), wherein R, R, R, Rand X are as defined under formula I.

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Munchwilen, Switzerland

Christian Lothschuetz