Boehringer Ingelheim Gmbh

Dr. Karl Thomae Gmbh

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Kg

C. H. Boehringer Sohn

Dr. Karl Tomae Gmbh

Christian Lillie

Walter Kobinger

Joachim Heider

Volkhard Austel

Herbert Koppe

Norbert Hauel

Werner Kummer

Helmut Stahle

Wolfgang Eberlein

Ludwig Pichler

Klaus Reinhold Noll

Rudolf Kadatz

Jurgen Dammgen

Berthold Narr

Manfred Reiffen

Willi Diederen

Andreas Bomhard

Manfred Psiorz

Eberhard Kutter

Wolfgang Hoefke

Wolfram Gaida

Helmut Pieper

Franz Esser

Walter Haarmann

Dietrich Arndts

Johannes Keck

Gerd Kruger

Andreas Zophel

David R Blake

Walter Kobinge

Ewa J Dowling

The present invention relates to the use of pharmaceutical preparations containing manganese superoxide dismutase in a low dose for treating diseases and conditions caused by free oxygen radicals.

Use of manganese superoxide dismutase (MN-SOD) for preparing

Disclosed are new cyclic amine derivatives of the formula I ##STR1## wherein the substituents are defined in the specification. These compounds are useful as for treating sinus tachycardia.

Cyclic amine derivatives, pharmaceutical compositions containing these

The present invention relates to new heteroaromatic amine derivatives of general formula ##STR1## wherein the substituents are defined hereinbelow, which have valuable pharmacological properties, particularly a heart rate lowering activity and a positive inotropic activity.

Heteroaromatic amine derivatives

Compounds of formula ##STR1## (the substituents R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are explained in the specification) may be prepared by conventional methods. Owing to their favorable activity profile the compounds may advantageously be used to treat certain heart and circulatory disorders.

1-phenoxy-3-amino-2-propanols use thereof

Heteroaromatic amine derivatives, pharmaceutical compositions containing

The present invention relates to new naphthyl derivatives of general formula ##STR1## wherein N represents the number 1 or 2,

Naphthyl derivatives, pharmaceutical compositions containing these

The invention relates to new heteroaromatic amine derivatives of formula ##STR1## wherein A represents a --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--or ##STR2## group and B represents a methylene, carbonyl or thiocarbonyl group or A represents a --CO--CO or ##STR3## group and B represents a methylene group, in which the carbon atom marked x is linked to the phenyl nucleus,

(2H)-3-benzazepin-2-ones, their pharmaceutical compositions and their

This invention relates to novel indole derivatives of the formula ##STR1## wherein A represents a --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## group and B represents a methylene, carbonyl, or thiocarbonyl group or A represents a --CO--CO-- or ##STR3## group and B represents a methylene group, E represents an alkylene group or a 2-hydroxy-n-propylene, 2-hydroxy-n-butylene, or 3-hydroxy-n-butylene group,

Novel indole derivatives and pharmaceutical compositions containing same

This invention relates to benzazepine derivatives of formula I ##STR1## wherein A is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--;

Benzazepine derivatives

This invention related to new aminotetralin derivatives of formula I ##STR1## wherein ##STR2## B is methylene or, when A is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --NH--CO-- or --CH.sub.2 --CO--, B can also be carbonyl or thiocarbonyl;

Aminotetralin derivatives

Compounds of the formula ##STR1## wherein A is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --NH--CO--, --CH.sub.2 --CO-- or ##STR2## where R.sub.7 is alkyl of 1 to 3 carbon atoms, and

Benzazepine derivatives, their pharmaceutical compositions and method of

Compounds of the formula ##STR1## wherein R is hydrogen or methyl, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.

Substituted

Compounds of the formula ##STR1## wherein A and B, together with each other and the respective carbon atoms to which they are attached, form a phenyl or pyridine ring;

2-Phenyl-pyrimidones

Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, hydroxyl or amino;

Substituted 2-phenylamino-2-imidazolines and salts thereof

Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each fluorine, chlorine, bromine or trifluoromethyl, and

Growing community of inventors

Vienna, Austria

Christian Lillie