Linde Aktiengesellschaft

Novartis Ag

Linde Gmbh

Christian Kunz

Dietrich Rottmann

Horst Corduan

Seth Alexander Ettenberg

Nicole Haubst

Winfried Elis

Andrew Paul Garner

Elizabeth Anne Reisinger Sprague

Matthew T Burger

Stefan Lochner

Dimitri Golubev

Tony Fleming

Vivek Rauniyar

Markus Waldhuber

Tobias Lautenschlager

Lars Kirchner

Gerhard Zapp

Joseph Anthony D'Alessio

Dietrich Rottman

Juergen Voit

Wolfgang Haag

Eusebio Manchado Robles

The invention relates to a method for a low-temperature air separation in which an air separation unit is used comprising a first rectification column and a second rectification column. The first rectification column is operated at a first pressure level, and the second rectification column is operated at a second pressure level below the first pressure level. Fluid which is oxygen-enriched compared to atmospheric air is drawn from the first rectification column in the form of one or more first material flows. At least one fraction of the fluid which has been drawn from the first rectification column in the form of the one or more first material flows is heated in a heat exchanger; a fraction of the fluid which has been heated in the heat exchanger is compressed using a compressor and is returned to the first rectification column.

Method and unit for low-temperature air separation

This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates comprising antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The application also discloses methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Antibodies to PMEL17 and conjugates thereof

The present invention relates to antibodies or fragments thereof that target a conformational epitope of a HER receptor. In particular, the invention relates to antibodies or fragments thereof that target a conformational epitope of HER3 receptor and compositions and methods of use thereof.

Antibodies for epidermal growth factor receptor 3 (HER3)

A process and apparatus for low-temperature fractionation of air in a distillation column system for nitrogen-oxygen separation ( ) introduces into first feed air stream ( ) into a distillation column system for nitrogen-oxygen separation. An oxygen-rich fraction ( ) from the distillation column system for nitrogen-oxygen separation is pressurized ( ) in liquid form and is added ( ) to a mixing column ( ). A heat transfer medium stream is introduced into the lower region of the mixing column ( ) and is brought into countercurrent contact with the oxygen-rich fraction ( ). Gaseous top product ( ) from the upper region of the mixing column ( ) is introduced into an additional column ( ). A liquid ( ) from the lower or middle region of the mixing column is introduced into the distillation column system. A krypton- and xenon-containing oxygen stream ( ) from the distillation column system is introduced into a krypton-xenon enriching column ( ) from which a krypton- and xenon-enriched fraction ( ) is obtained. A krypton- and xenon-depleted top fraction ( ) is obtained from the upper region of the additional column ( ).

Air fractionation process and installation with mixing column and krypton-xenon recovery

The process and device are used to obtain a compressed product by low temperature separation of air in a rectification system which has a pressure column and a low pressure column. A first flow of compressed and purified feedstock air is cooled in a main heat exchanger system and is fed into the pressure column. At least one fraction from the pressure column is expanded and fed into the low pressure column. An oxygen-rich fraction from the low pressure column is liquid-pressurized and delivered to a mixing column. A heat exchange medium is fed into the lower area of the mixing column and is brought into countercurrent contact with the oxygen-rich fraction. A gaseous top product is removed from the upper area of the mixing column. A product fraction is removed from the rectification system, liquid-pressurized, vaporized in indirect heat exchange with the gaseous top product of the mixing column and is withdrawn as the compressed product. Indirect heat exchange is carried out for vaporization of the liquid-pressurized product fraction in the main heat exchanger system.

Process and device for obtaining a compressed product by low temperature separation of air

The process and the apparatus serve for separating a gas mixture in a separation plant. A feed gas ( ) is introduced into a compressor system ( ) and then into the separation plant. In the event of loss or partial loss of the compressor system ( ) of the first feed gas compressor ( ), a first auxiliary stream ( ) which has approximately the composition of the first product stream or approximately the composition of the feed gas is compressed ( ) to at least approximately the first pressure and is recirculated to the separation plant.

Process and apparatus for separating a gas mixture with emergency operation

In a single column distillation system for obtaining gaseous and liquid nitrogen with a variable proportions of liquid product by low-temperature separation from air, a first portion ( ) of nitrogen-rich fraction ( ) is fed downstream of circulation compressor ( ) to the liquefaction chamber of a condenser-evaporator ( ) associated with the single column and condensed under a pressure higher than the operating pressure of the single column ( ). A liquid oxygen-enriched fraction ( ) from the distillation column system is at least partially evaporated in the evaporation chamber of condenser-evaporator ( ). A portion ( ) of nitrogen-rich liquid ( ) from condenser-evaporator ( ) is drawn off at least at times as liquid product. A second oxygen-enriched gas ( ) is removed from one of columns ( ) of the distillation system and/or from the evaporation chamber of condenser-evaporator ( ), machine expanded( ), and heated in main heat exchanger ( ).

Process for obtaining gaseous and liquid nitrogen with a variable proportion of liquid product

For obtaining gaseous nitrogen by low-temperature separation from air, a distillation column system has a single column ( ). Compressed air ( ) is cooled in a main heat exchanger ( ) and fed ( ) to single column ( ). A nitrogen-rich fraction ( ) is drawn off from the distillation column system and compressed at least in part in a circulation compressor ( ). A first part ( ) of nitrogen-rich fraction ( ) is fed downstream from circulation compressor ( ) to the liquefaction chamber of a condenser-evaporator ( ) and is condensed under a pressure higher than the operating pressure of single column ( ), so to form nitrogen-rich liquid ( ). A liquid oxygen-enriched fraction ( ) from the distillation column system is at least partially evaporated in the evaporation chamber of condenser-evaporator ( ). A first oxygen-enriched gas ( ) formed in the evaporation chamber of condenser-evaporator ( ), is introduced into single column ( ). A second portion ( ) of the nitrogen-rich fraction ( ) is drawn off at least at times as gaseous nitrogen product. A second oxygen-enriched gas ( ) is removed from the evaporation chamber of condenser-evaporator ( ), work expanded ( ), and heated in main heat exchanger ( ).

Process for obtaining gaseous nitrogen

For producing ultrapure nitrogen by low-temperature fractionation of air in a rectification system having at least one rectification column, compressed and purified feed air is conducted into a high pressure column, an oxygen-free pressurized nitrogen fraction is produced from the high pressure column, conducted into a low-pressure column and in the low-pressure column carbon-monoxide-free low-pressure nitrogen is produced as overhead gas. The oxygen-free pressurized nitrogen fraction (,) is either taken off in the liquid state from an upper region of the high pressure column or is provided from a liquid tank (,) containing stored oxygen-free nitrogen and the oxygen-free pressurized nitrogen fraction (,) is expanded into the bottom-heated low-pressure column (,). Ascending vapour in the lowpressure column (,) by mass transfer with and an ultrapure nitrogen reflux applied at the top of the low-pressure column (,) and is freed from carbon monoxide using ultrapure nitrogen, withdrawn as carbon-monoxide-free overhead gas (,) at the top of the low-pressure column (,). After a pressure increase the overhead (,), is partially liquefied, and the liquefied part (,) is expanded into a bottom-heated He&mdash;Ne&mdash;H,column (,) from which the ultrapure nitrogen (,) is withdrawn in the liquid state.

Process for producing ultrapure nitrogen

The process and the apparatus serve to produce pressurized nitrogen by low-temperature fractionation of air in a rectification system which has a pressure column (,) and a low-pressure column (,). Feed air (,) is passed into the pressure column (,). An oxygen-containing liquid fraction (,) is taken off from the pressure column (,) and fed into the low-pressure column (,). Gaseous nitrogen (,) from the low-pressure column (,) is at least partially condensed in a top condenser (,) by indirect heat exchange with an evaporating liquid (,). Nitrogen from the low-pressure column is produced as gaseous pressurized nitrogen product (,) at a pressure which is higher than the operating pressure of the low-pressure column (,). Liquid nitrogen (,) withdrawn from the low-pressure column is brought (,) in the liquid state to a pressure which exceeds the pressure of the low-pressure column (,). The pressurized liquid (,) is evaporated in a product evaporator (,) by indirect heat exchange with a heat-transfer medium (,) and is subsequently produced as gaseous pressurized nitrogen product (,). (FIG.,)

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Munich, Germany

Christian Kunz