Bayer Aktiengesellschaft

Christian Kohlsdorfer

Romanis Fruchtmann

Siegfried Raddatz

Reiner Muller-Peddinghaus

Pia Theisen-Popp

Klaus Mohrs

Klaus-Helmut Mohrs

Michael Matzke

Armin Hatzelmann

Elisabeth Perzborn

Friedel Seuter

Burkhard Fugmann

Erwin Bischoff

Rudi Grutzmann

Bernhard Pelster

Hartwig Muller

Klaus Frobel

Bruno Rosen

Karlheinz Weber

Guenther Karmann

Hans Plumpe

Pia Theisen

The novel quinolin-2-yl-methoxybenzylhydroxyureas can be prepared by reaction of appropriate ketones with hydroxylamine and reduction of the ketoximes and subsequent reaction with isocyanates. The new substances can be employed as active substances in medicaments.

Quinolin-2-yl-methoxybenzylhydroxyureas

A (quinolin-2-yl-methoxy) phenylacyl-sulphonamide or -cyanamide of the formula ##STR1## and physiologically acceptable salts thereof. The (quinolin-2-yl-methoxy)phenylacylsulphonamide or -cyanamide is useful as an active compound in medicaments, particularly as a lipoxygenase inhibitor.

Substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphon-amides and

The title compounds are prepared either by reacting the corresponding halogenomethylquinolines with substituted phenols, optionally subsequently alkylating these or hydrolysing esters to acids, or by reacting phenyl-substituted quinolinecarboxylic acid derivatives with sulphonamides. The new phenyl-substituted quinolines are utilizable as active substances in medicaments, in particular as lipoxygenase inhibitors.

2-substituted quinolines, and their use in medicaments

Substituted mandelic acid derivatives can be prepared by reaction of glyoxylic esters with Grignard compounds. The substituted mandelic acid derivatives are suitable as active compounds in medicaments, in particular for medicaments which inhibit leukotriene synthesis.

Substituted mandelic acid derivatives and their use in medicaments

Heterocyclically substituted quinolylmethoxyphenylacetamides are prepared by amidation of corresponding carboxylic acids. The compounds can be used in medicaments, in particular those having lipoxygenase-inhibiting action.

Heterocyclically substituted quinolylmethoxy-phenylacetamides

New phenylsulphonamide of the formula in which ##STR1## R.sup.1 represents a pyridyl, quinolyl or isoquinolyl radical which is unsubstituted or substituted by halogen, alkyl, cycloalkyl, alkoxy, cyano, nitro, halogenoalkyl, halogenoalkoxy, alkoxycarbonyl or alkylsulphonyl,

Antiflammatory quinolin methoxy phenylsulphonamides

For inhibiting lipoxygenzce, (quinolin-2-yl-methoxy) phenylacetic acid derivatives containing cyclic substituents of the formula ##STR1## in which A, Q, D, E, G, T and M are hydrogen or various radicals,

(Quinolin-2-yl-methoxy)phenylacetic acid derivatives containing cyclic

A method of treating a patient to reduce or prevent an acute or chronic inflammation or an ischaemic state which comprises administering to such patient an effective amount therefor of efomycin A, E or G.

Efomycins A, E and G as antiinflammatory agents

Inhibiting leucotriene synthesis in patients with novel substituted N-(quinolin-2-yl-methoxy)benzylsulphonyl-urea of the formula ##STR1## in which A, B, D, E, G, K and M each independently is H, OH, halogen, CF.sub.3, OCF.sub.3, COOH, alkyl, alkoxy, alkoxycarbonyl or aryl,

Substituted N-(quinolin-2-yl-methoxy) benzyl-sulphonylurea leukotriene

Inhibiting leucotriene synthesis in patients with novel disubstituted (quinolin-3-yl-methoxy)phenylacetic acid derivatives of the formula ##STR1## in which A, B, D, E, G, K and M each independently is H, OH, halogen, CF.sub.3, OCF.sub.3, COOH, alkyl, alkoxycarbonyl or aryl,

Leukotriene synthesis-inhibiting disubstituted (quinolin-2-yl-methoxy)

Substituted (quinolin-2-ylmethoxy)phenyl-thio-ureas of the formula ##STR1## in which A, B, D, E, G, K and M

Substituted (quinolin-2-yl-methoxy)phenylthioureas

New phenylsulphonamides of the formula in which ##STR1## R.sup.1 represents a pyridyl, quinolyl or isoquinolyl radical which is unsubstituted or substituted by halogen, alkyl, cycloalkyl, alkoxy, cyano, nitro, halogenoalkyl, halogenoalkoxy, alkoxycarbonyl or alkylsulphonyl,

Substituted phenylsulphonamides

A quinolin-2-yl-methoxy)phenylacyl-sulphonamide or -cyanamide of the formula ##STR1## in which A, B, D, E, F and G are identical or different and

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Erftstadt, Germany

Christian Kohlsdorfer