Boehringer Ingelheim International Gmbh

Otto Bock Healthcare Gmbh

Christian Klein

Steffen Steurer

Irene Waizenegger

Matthias Grauert

Christoph Hoenke

Matthias Hoffmann

Stefan Scheuerer

Steffen Breitfelder

Martin Steegmaier

Darryl McConnell

Trixi Brandl

Andreas Schoop

Peter Ettmayer

Andreas Mantoulidis

Frank Hilberg

Dirk Kessler

Bodo Betzemeier

Ulrike Weyer-Czernilofsky

Udo Maier

Maria Impagnatiello

Bernd Krist

Thomas Gerstberger

Ralph Brueckner

Andreas Zoephel

Michael Gmachl

Charlotte Reither

Norbert Schweifer

Oliver Simon

Georg Dahmann

Stephan Karl Zahn

Ioannis Sapountzis

The present invention encompasses compounds of general formula (1), wherein the groups Rto Rand L are defined as in claim, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties. 

Chemical compounds

The present invention encompasses compounds of general formula (1) wherein the groups Rto R, X, X, X, Land Lare defined as in claim, which are suitable for the treatment of diseases characterized by excessive or anomalous cell proliferation, and the use thereof in such a treatment. 

Pyrido [5, 4-D] pyrimidines as cell proliferation inhibitors

The present invention encompasses compounds of the general formula (1) in which

Thiazolyl-dihydro-indazoles

Thiazolyl-dihydro-indazole

A fitting including an electrode assembly mounted and sealed therein. The fitting configured to be positioned within an aperture in a wall of a socket of a prosthetic apparatus. The prosthetic apparatus may include an external socket that receives and is attached to the socket as an internal socket. The electrode assembly has one or more skin contacts for conduction of myoelectrical signals to a prosthetic system. The fitting includes a groove and a retention rim to secure and seal the fitting within the aperture in the socket wall, in order to prevent the passage of air and moisture from the interior of the socket when a stump of a limb is received therein. A unidirectional valve provides for the release of air from the interior of the socket.

Internal socket and fitting system for a prosthesis

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Vienna, Austria

Christian Klein