Centogene Ag

Centogene Gmbh

Christian Junghanss

Matthias Beller

Moritz Frech

Anahit Pews-Davtyan

Jan Lukas

Arndt Rolfs

Christian Eisenloeffel

The present invention is related to a compound of formula (I): a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, a metabolite thereof or a prodrug thereof;for use in a method for the treatment and/or prevention of cancer, whereinX is selected from the group consisting of N&#x2014;R, O and S;Ris selected from the group consisting of alkyl, cycloalkyl, aryl, arylalkyl and hydrogen;Ris selected from the group consisting of indolyl, substituted indolyl, azaindolyl and substituted azaindolyl; and Ris selected from the group consisting of aryl, substituted aryl, unsubstituted heteroaryl, heterocyclyl and substituted heterocyclyl.

Use of maleimide derivatives for preventing and treating cancer

The present invention is related to a compound of formula (I) a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, a metabolite thereof or a prodrug thereof; for use in a method for the treatment and/or prevention of cancer, wherein X is selected from the group consisting of N&#x2014;R, O and S; R1 is selected from the group consisting of alkyl, cycloalkyl, aryl, arylalkyl and hydrogen; Ris selected from the group consisting of indolyl, substituted indolyl, azaindolyl and substituted azaindolyl; and Ris selected from the group consisting of aryl, substituted aryl, unsubstituted heteroaryl, heterocyclyl and substituted heterocyclyl. 

The present invention is related to a compound of formula (I): a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, a metabolite thereof or a prodrug thereof; for use in a method for the treatment and/or prevention of leukemia, wherein X is selected from the group consisting of N&#x2014;R, O and S; Ris selected from the group consisting of alkyl, cycloalkyl, aryl, arylalkyl and hydrogen; Ris selected from the group consisting of indolyl, substituted indolyl, azaindolyl and substituted azaindolyl; and Ris selected from the group consisting of aryl, substituted aryl, unsubstituted heteroaryl, heterocyclyl and substituted heterocyclyl. 

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Rostock, Germany

Christian Junghanss