Sanofi-aventis

Synthelabo

Sanofi

Christian Hoornaert

Ahmed Abouabdellah

Antonio Almario Garcia

Jean Jeunesse

Jacques Froissant

Jean-Claude Muller

Patrick Andre Lardenois

Adrien Tak Li

Luc Even

Gihad Dargazanli

Frederic Puech

Florence Medaisko

Michele Bas

Philippe Burnier

Antoine Ravet

Nigel R Beeley

Michel Aletru

Tak Adrien Li

Marc Daumas

Gary Mccort

Guy Rossey

Frank Marguet

Isaac Chekroun

Jean Claude Muller

Paul Howard Williams

Jose Ruiz-Montes

Pascal George

Frédéric Puech

Helene Greciet

Manuel Bedoya-Zurita

Regine Bartsch

Regine Bartsch-Li

Dorothee Cheuret

Antonio Almario-Garcia

Genevieve Dellac

Régine Bartsch

Dorothée Cheuret

The disclosure relates to hexafluoroisopropyl carbamate derivatives of general formula (I): in which:

Hexafluoroisopropyl carbamate derivatives, their preparation and their therapeutic application

A compound corresponding to general formula (I): in which Rrepresents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C-C)cycloalkyl-O&#x2014; or (C-C)cycloalkyl(C-C)alkoxy groups; Rrepresents either a group of general formula CHRCONHRin which Rrepresents a hydrogen atom or a methyl group and Rrepresents a hydrogen atom or a (C-C)alkyl, (C-C) cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics

The invention relates to a compound having general formula (I): Wherein m, Rand Rare as defined herein. The invention also relates to the use of the compound in therapeutics. More specifically, the compounds of the invention are inhibitors of the FAAH enzyme, and therefore, can be used for the treatment of various disorders associated with FAAH enzyme, which include in a non-limiting manner, pain, eating disorders, neurological and psychiatric pathologies, among other disorders.

Derivatives of 1-piperazine- and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the FAAH enzyme

The invention relates to the triazolopyridine carboxamide derivative and trizolopyrimidine carboxamide derivative of general Formula (I): Wherein X, Rand Rare as defined herein. The invention further relates to preparation methods and therapeutic use thereof.

Triazolopyridine carboxamide derivatives and triazolopyrimidine carboxamide derivatives, preparation thereof and therapeutic use thereof

Therapeutic uses of a compound corresponding to the general formula (I): in which A=N or CR; R=H, F, OH, CN, CF, C-alkyl, C-alkoxy; n=2 or 3 and m=2 when A=N; n=1, 2 or 3 and m=1 or 2 when A=CR; B=covalent bond or C-alkylene; R=optionally substituted heteroaryl; R=CHRCONHR; R=H or C-alkyl; R=H, C-alkyl, C-cycloalkyl, C-cycloalkyl-C-C-alkylene;in the form of a base, an acid-addition salt, a hydrate or a solvate.

Therapeutic uses of derivatives of piperidinyl- and piperazinyl-alkyl carbamates

The invention relates to a compound of formula (I): Wherein m, n, X, Y, R, R, Rand Rare as defined herein. The invention also relates to the use of same in therapeutics.

Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics

The present invention comprises alkylpiperazine- and alkylhomopiperazine carboxylates and their derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of disease and other pathological conditions are not generated and the incidence of the disease is greatly reduced.

Derivatives of alkylpiperazine- and alkylhomopiperazine-carboxylates, preparation method thereof and use of same as fatty acid amido hydrolase enzyme inhibitors

The invention relates to the triazolopyridine carboxamide derivatives of general formula (I): Wherein X, A, Rand Rare as defined herein. The invention further relates to preparation methods and therapeutic use thereof.

Triazolopyridine carboxamide derivatives, preparation thereof and therapeutic use thereof

The invention relates to the triazolopyridine carboxamide derivatives and triazolopyrimidine carboxamide derivatives of general formula (I): Wherein X, A, Rand Rare as defined herein. The invention further relates to preparation methods and therapeutic use thereof.

The present invention comprises peridinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of a large variety of diseases and other pathological conditions are not generated and the incidence of the disease is greatly reduced.

Piperidinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase enzyme inhibitors

A compound corresponding to general formula (I): in which Rrepresents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C-C)cycloalkyl-O&#x2014; or (C-C)cycloalkyl(C-C)alkoxy groups; Rrepresents either a group of general formula CHRCONHRin which Rrepresents a hydrogen atom or a methyl group and Rrepresents a hydrogen atom or a (C-C)alkyl, (C-C)cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

Derivatives of 1-piperazine-and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the FAAH enzyme

The present invention is directed to compounds and compositions for the treatment of neurological diseases that cause neurogenic and neuropathic pain, inflammatory diseases, renal ishaemia, cardiovascular disease and other pathologies caused by the presence of endogenous cannabinoids and or other substrates resulting from the metabolic activities of fatty acid amido hydrolase (FAAH). These compounds are represented by the formula alkylene group; a salt thereof, or a hydrate or a solvate of said compound or said salt; where the variables are as defined in the attached specification.

Derivatives of heteroaryl-alkylcarbamates, methods for their preparation and use thereof as fatty acid amido hydrolase enzyme inhibitors

The present invention provides a compound of the formula (I): in which R, R, R, A and n are described and set forth more fully herein. Also provided are their preparation and their application in therapy.

Arylalkylcarbamate derivatives and production thereof

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Antony, France

Christian Hoornaert