Novo Nordisk A/s

Novo Nordisk Healthcare Ag

Christian Hoejris Nielsen

Bo Radmer

Matias Melander

Jesper Peter Windum

Tom Hede Markussen

Christian Plambech

Soeren Dyring Jensen

Mie Haraldsted

Roshan Hakkim

Henrik Bengtsson

Jim Radmer

Morten Revsgaard Frederiksen

Lars Eilertsen

Ebbe Kiilerich

Simon Munch Pedersen

Jonas Hjortlund

Graham Hinde

Torben Stroem Hansen

Klaus Bendix

Claus Urup Gjoedesen

Ronan Carroll

Emil Gram Spork

Mikkel Avlund

Knud Winther

Martin Majdall Petersen

Kristoffer Aagaard Eriksen

Hans Hemmingsen

Martin Rasmussen

Bas Kamp

The invention relates to an injection device for injecting a liquid drug. The injection device comprises a housing assembly supporting a non-removable cartridge having an interior chamber containing the liquid drug to be injected and a reusable needle cannula connected to the cartridge. A needle shield assembly provided with a cleaning chamber containing a volume of a cleaning agent for cleaning at least the distal tip of the needle cannula between subsequent injections is further provided. The needle shield assembly is axially movable in a proximal direction in relation to the housing assembly from a first position to a second position upon rotation of at least a part of the needle shield assembly, wherein the first position is a position in which the distal tip of the needle cannula is located inside the cleaning chamber thereby cleansing the distal tip of the needle cannula, and the second position is a position in which the distal tip of the needle cannula is located outside and distal to the cleaning chamber for equalizing the pressure in the cartridge.

Medical injection device with a cleaning chamber

The present invention relates to a torsion spring driven injection device for delivering set doses of a liquid drug. The injection device mechanism is encapsulated in a housing which also stores the cartridge containing the liquid drug. A needle cannula which is in liquid communication with the interior of the cartridge and which has a distal tip is shielded by a telescopically movable needle shield is used to inject the set dose. The needle cannula is preferably used for multiple injections and cleaned between subsequent injections. The drive mechanism further comprises a nut member engaging the piston rod and releasable coupled to the housing to operate as a pressure relief mechanism. The telescopically movable needle shield covering the distal tip of the needle cannula is formed to lock the nut member to the housing during injection.

Torsion spring driven injection device

The present invention relates to an injection apparatus for injecting a pharmaceutical liquid drug into the skin of a user. The injection apparatus can be in form of an injection device carrying a needle cannula or in the shape of a needle assembly () attachable to an injection device. The outer shell of the injection apparatus is a protective shield () divided into different segments (). These segments are preferably spaced from each other in the longitudinal direction to move individually in the axial direction. Further, the segments are provided with tilting means () which are activated to move neighboring segments () apart upon relative axial movement of one or more segments () whenever an uneven force is applied to the distal end of the shield.

Shielding mechanism for an injection apparatus

Disclosed is a medical injection device () comprising a needle assembly () having a cannula () and a telescopic shield () for covering the distal tip () in a no use situation. The telescopic shield further carries a cleaning reservoir () for cleaning the needle cannula between two subsequent injections. The cleaning reservoir is provided with an opening () connecting to an overflow reservoir () such that the cleaning liquid contained in the cleaning reservoir can retract and expand upon temperature changes and does not enter the needle lumen instead. In one example, the overflow reservoir is formed as a channel ().

Pen-type drug injection device having multiple-use needle module with needle cleaning reservoir

The invention relates to an injection device for self-administration of doses of a liquid drug. The injection device carries a needle cannula () which is concealed by a telescopically movable shield (). Further a stopping means () interconnects the shield with the helical rotatable scale sleeve () such that the shield can only be operated proximally when the scale sleeve is rotated away from its zero position. Once the scale sleeve returns to its zero position during expelling of the dose, the shield and the stopping means is allowed to slide distally and thus return to the locked position.

Drive mechanism for an injection device

The present invention provides a drug delivery device () comprising a dose delivery mechanism and a blocking structure () for preventing inadvertent activation of the dose delivery mechanism. The blocking structure () enables and disables the dose delivery mechanism dependent on the position of a needle holder () relative to a drug cartridge holder ().

Drug delivery device with movable needle mount

The present invention relates to medicament injection devices (). A cartridge () with a septum and a needle unit () having front and rear needles () are configured for relative movement from a state where the septum is sealed to a state where the septum is pierced by the rear needle (). The injection device () may include a needle shield () and be configured for piercing the septum by the rear needle () when the front needle () is operated relative to the needle shield (). The injection device () may also include a damping mechanism configured for limiting the speed of movement of the cartridge relative to the needle unit. The injection device () may also include an indicator generating a signal when a piston driver has travelled the complete stroke length, wherein the indicator has a deflection element that is deflected prior to or during movement of the cartridge relative to the housing.

Medical injection device

The present invention relates to injection devices for injecting a dose of a medicament. The injection device () incorporates a housing (), a needle assembly () and a cover (). The needle assembly () comprises an injection needle () accommodated in a needle container () having an opening which in a storage state of the injection device () is sealed by a film seal (). The cover may include sections () arranged movable relative to the housing (). The injection device () is so configured that upon movement of the cover sections () relative to the housing () the film seal () is changed from a sealing state to an unsealing state for shifting the injection device () into a ready-to-administer state.

The present invention relates to an automatic torsion spring based injection device having a dial-up/dial-down mechanism by which a dose can be set by rotating a dose setting member in a first direction and which dose size can be reduced by rotating the same dose setting member in a second and opposite direction. The dial-up/dial-down mechanism operates a torsion spring which is strained when setting a dose and unstained when rotating the dose setting element in the second direction. In order to secure the torsion spring when strained, a ratchet arm () following the rotation of the dose setting element in the first direction, engages a toothed element () such that engagement of the at least one ratchet arm () with teeth () of the toothed element () prevents unwinding of the torsion spring, and wherein the rotation of the dose setting member in the first direction moves the ratchet arm () from one tooth () to the subsequent tooth () of the toothed element (), and rotation of the dose setting member in the second direction lowering the set dose activates the ratchet arm () to disengage the teeth () of the toothed element () and thereby allow the torsion spring to move the ratchet arm () in the second direction to the previous tooth () such that the force accumulated in the torsion spring reduces incrementally. In order to provide a smooth movement when dialing down the set dose, the at least one ratchet arm () is provided o a ratchet tube () which carries friction teeth () which engage with a cam curve () of the toothed element, dampening the movement of the ratchet arm () by the torsion spring.

Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism

The present invention relates to a medical device () comprising a first container () holding a first medium and defining a general axis, a second container () holding a second medium, and fluid connection means () for establishing fluid connection between the first container () and the second container (), the fluid connection means () being arranged at least partially between the first container () and the second container (). The device further comprises a cover receiving portion () and a cover () removably mounted thereon to shield at least an operable portion of the first container (). The cover () is operatively coupled with the fluid connection means () and configured to cause a relative converging motion between at least one of the first container () and the fluid connection means () and the second container () and the fluid connection means () in response to a dismounting of the cover () from the cover receiving portion ().

Pre-assembled fluid transfer arrangement

The present invention relates to injection devices for injecting a medicament from a cartridge () through a needle cannula (). The injection device () includes an actuator () for driving a piston driver () and includes an end of stroke limiter (). When the piston driver () is arrested by the end of stroke limiter () a shielding driver () is automatically triggered to actively shift the needle cannula () into a shielded state. The injection device may include a fluid dispensing interruption mechanism that automatically interrupts fluid flow when the piston driver has moved a predetermined stroke length. The injection device may also include a single pre-stressed spring acting exclusively in a linear compression mode or exclusively in a torsion mode and adapted to sequentially drive the device to enable fully automatic operation. The invention also relates to a method of sterilizing a needle cannula assembly.

Growing community of inventors

Copenhagen, Denmark

Christian Hoejris Nielsen