Wisconsin Alumni Research Foundation

University of Massachusetts

University of Hamburg

Christian Heyn

Robert H Blick

Wolfgang Hansen

Abhishek Bhat

Paul Gwozdz

Zlatan Aksamija

Jonathan Rodriguez

Hyunseok Kim

A nanoscale-sized pore positioned between two reservoirs may sequence biomolecules by detecting changes in the emitted light due to a change in charge of portions of the biomolecules as they pass through the pore such as affect an emission frequency of a quantum structure proximate to the pore opening. The nanopores may be fabricated using local droplet etching whose randomness is accommodated by lowering the droplet density to permit isolation of nanopores in tiles that may be adhered to an underlying supporting substrate having an aligned opening. The nanopore-tiles may be integrated with commonly applied glass chips and may be employed in microfluidic circuitry.

High-speed DNA sequencing with optically active nanopore

A detector suitable for mass spectroscopy uses a thin membrane that converts the kinetic energy of impinging molecules into corresponding photons, the latter detected with a suitable photosensor. The arrival of molecules at the membrane is detected by detection of the corresponding photons.

Mass spectrometer detector using optically active membrane

Growing community of inventors

Lueneburg, Germany

Christian Heyn