Leibnizinstitut Für Naturstoff-Forschung Und Infektionsbiologie E. V. -Hans-Knöll-Institut

Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt

Leibniz-Institut Für Naturstoff-Forschung Und Infektionsbiologie

Leibniz-institut Fuer Naturstoff-forschung Und Infektionsbiologie

Leibniz-institut Fuer Naturstoff-forschung Und Infektionsbiologie E.v. Hans-knoell-institute (hki)

Leibniz-institut Für Naturstoff-forschung Und Infektionsbiologe E. V. - Hans-knöll-institut -

Christian Hertweck

Hans-Martin Dahse

Florian Kloss

Kirstin Scherlach

Ulrike Protzer

Axel Brakhage

Martin Roth

Hans-Wilhelm Nuetzmann

Veit Haensch

Toni Neuwirth

Ruth Brack-Werner

Thorger Lincke

Keishi Ishida

Swantje Behnken

Mikko Metsae-Ketelae

Tom Bretschneider

Nico Ueberschaar

Martina Werneburg

Martha Schneider

Manfred Rösner

Markus Helfer

Gulimila Shabuer

Michael Cyrulies

Katharina Graupner

Gerald Lackner

Manfred RÖSNER

Sacha Pidot

Mikko Metsae-Ketalae

The present invention relates to a method for the metal-free preparation of a biaryl compound by a photosplicing reaction and its use in the preparation of chemical compounds, preferably of active ingredients e.g. in the fields of pharmaceuticals and agrochemicals. In particular, it refers to a method for the regiocontrolled preparation of a biaryl compound of formula (I): Ar&#x2014;Ar' by photochemically reacting a precursor compound of formula (II): Ar&#x2014;L&#x2014;Ar&#x2032; to form a biaryl compound of general formula: Ar&#x2014;L&#x2014;Ar&#x2032;(II)&#x2192;Ar&#x2014;Ar&#x2032; (I) wherein Ar and Ar&#x2032;, independently of each other, represent an unsubstituted or substituted C6-C20 aryl group or a heteroaryl group with 5-20 ring atoms selected from carbon, nitrogen, oxygen and sulfur, and L represents a group &#x2014;X&#x2014;Y&#x2014;Z&#x2014; as defined herein. The biaryl compounds are generally suitable as intermediates or key building blocks in a very broad spectrum of organic chemical syntheses and their respective utilities. Their use within the field of synthesis of active ingredients is an aspect of the invention, and their use in the preparation of pharmaceutically active ingredients is particularly preferred.

Method for the metal-free preparation of a biaryl by a photosplicing reaction and their uses

The present invention relates to compounds and compositions for use in methods of treating and/or preventing conditions, disorders or diseases that are mediated or caused by a virus. 

Pyrone derivatives for use as antiviral agents

The present invention relates to novel Chartreusin analogues of formula (I), pharmaceutical compositions comprising the same and to their use for the treatment of cancer and other diseases.

Chartreusin analogues

This invention relates to the field of biologically active compounds and specifically to phaeofungins, of the general formula (I) or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof, pharmaceutical compositions comprising these compounds, methods for the production of the phaeofungins and their use as fungicide, antibiotic as well as antitumor agent. 

Benzopyranobenzothiazinones and their use as fungicides, antibiotics and antitumor agents

This invention relates to the field of biologically active compounds and specifically to closthioamides, pharmaceutical compositions comprising these compounds, and their use as antibiotic, antifungal, and/or cytotoxic agent.

Closthioamides, compositions, and methods for treating bacterial or fungal infections or cancer

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Leipzig, Germany

Christian Hertweck