Institut National De La Sante Et De La Recherche Medicale

Universitè De Montpellier

Centre Hospitalier Universitaire De Montpellier

Université D'auvergne

Centre National De La Recherche Scientifique

Université Clermont Auvergne

Christian Hamel

Thierry Durand

Céline Crauste

Joseph Vercauteren

Philippe Brabet

Laurent Guillou

Claire Vigor

David Cia

Vasiliki Kalatzis

Marie Pequignot

Nicolas Cereso

The present invention relates to a compound of formula (I) wherein: i is 0 or 1; j is 0 or 1; k is 0 or 1; Rand Rare in particular H, (C-C)alkyl, or a group of formula C(O)R; R is a, linear or branched, alkyl radical, comprising at least 19 carbon atoms; Ris H and k=0 when j=1; or, when j=0, Ris &#x2014;C(O)R or -L-C(O)R; L, U and L&#x2033; are linkers; wherein, when j=0, at least one of the groups R; Rand Rcomprises a radical R. 

Lipophenol compounds and uses thereof

The present invention relates to methods and pharmaceutical compositions for expressing a polynucleotide of interest in the retinal pigment epithelium of a subject. In particular, the present invention relates to a method for selectively expressing a polynucleotide of interest in the retinal pigment epithelium in an eye of a subject in need thereof comprising the step of transducing the retinal pigment epithelium with an amount of a rAAV2/5 vector containing the polynucleotide of interest.

Methods and pharmaceutical compositions for expressing a polynucleotide of interest in the retinal pigment epithelium of a subject

Growing community of inventors

Montpellier, France

Christian Hamel