Basf Aktiengesellschaft

Christian Dully

Klaus Ditrich

Johann-Peter Melder

Markus Frede

Hans-Jurgen Weyer

Christoph N&uuml;bling

Achim Weitze

The present invention relates to a process for resolving racemates of alkoxy-substituted primary amines by reacting with an ester in the presence of a lipase and subsequently separating the optically active amide which is formed from the unreacted optically active amine. This is followed where appropriate by hydrolysis of the optically active amide, separation of the optically active amine produced thereby from the acid from which the ester is derived, racemization and recycling of the unwanted enantiomer of the amine, and esterification and recycling of the acid.

Enzyme-catalyzed racemic cleavage of primary amines

The process for purifying an .alpha.-, .beta.- or .gamma.-substituted carboxylic acid or a salt or an ester thereof or a mixture of two or more thereof from an aqueous solution which contains an .alpha.-, .beta.- or .gamma.-substituted carboxylic acid or a salt or an ester thereof or a mixture of two or more thereof and at least one polyol or at least one amino alcohol, wherein the solution is treated by electrodialysis.

Purification of .alpha.-, .beta.- or .gamma.-substituted carboxylic acids

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Ludwigshafen, Germany

Christian Dully