Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

Amgen Research (Munich) Gmbh

Takeda Gmbh

Amgen Research Gmbh

Christian De Muynck

Peter Iwatschenko

Gerhard Pohlmann

Wolfgang Koch

Horst Windt

Markus Rast

Friedemann Taut

Daniela Rahmel

Wolfram Steinhilber

Pernille Dybendal Pedersen

Thomas Urbig

Thomas Boehm

Gerhard Becker

A device and system for delivering an aerosol to a patient on ventilatory support comprise a contact componentto be positioned in contact with a respiratory organ. The contact componentcomprises a lumenthrough which breathing gas and an aerosol are delivered to lungs of a patient.

Device and system for delivery of an aerosol to a patient on ventilatory support

The present invention relates to aqueous formulations comprising at least 20 mg/ml of a compound neutralizing GM-CSF, a lyoprotectant and an amino acid and/or a buffer. The ingredients of the formulation preferably provide stability to the compound neutralizing GM-CSF in view of lyophilization, storage and reconstruction. In a preferred aspect, the formulation, e.g. after reconstruction, is for use in therapy, preferably for use in the treatment of inflammatory and autoimmune disorders, preferably including allergic and psoriatic disorders, as well as arthritic and asthmatic disorders. Furthermore, a kit comprising the formulation of the invention is provided.

Lyophilized formulation comprising GM-CSF neutralizing compound

The invention relates to aerosolized and humidified particles comprising a therapeutically active substance which can be obtained by suspending dry inhalable particles in a carrier gas, adding water vapor and causing condensation of water on the particles. The invention further relates to methods to generate these particles, and apparatus useful to carry out such methods.

Humidified particles comprising a therapeutically active substance

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Constance, Germany

Christian De Muynck