Rwth Aachen

Caprotec Bioanalytics Gmbh

Institute of Biotechnology

Christian Dalhoff

Saulius Klimasauskas

Elmar Weinhold

Michael Sefkow

Thomas Lenz

Mathias Dreger

Grazvydas Lukinavicius

G Lukinavicius

The invention relates to a method for tagging, identifying and isolating a target cell, wherein the cell is contacted with a capture compound comprising a small molecule moiety, for example a pharmaceutical drug molecule, capable of selectively binding with the cell surface of the target cell, and a function that is capable to covalently or quasi-covalently bind to a surface as a marker or tagging function. In some embodiments the capture compound also includes a photoactivatable reactivity function. The capture compound attaches to a particle that mediates identification or isolation of the tagged cell.

Isolation and functional identification of cells

S-Adenosyl-L-methionine analogs of formula (I): are disclosed wherein R comprises a carbon-carbon double bond, carbon-sulfur double bond, carbon-nitrogen double bond, -a carbon-carbon triple bond, carbon-nitrogen triple bond or an aromatic carbocyclic or heterocyclic system in &#x3b2;-position to the sulfonium center, Xis an organic or inorganic anion carrying one or more negative charges, Z is &#x2014;CRR&#x2014;, &#x2014;O&#x2014;, &#x2014;S&#x2014; or &#x2014;NR&#x2014; and R, Rand Rare independently selected from H, D and C&#x2014;C alkyl; as well as complexes with a methyltransferase, pharmaceutical compositions, methods for modifying a biomolecule, and methods for detecting sequences specific methylation of biomolecules.

S-adenosyl-L-methionine analogs with extended activated groups for transfer by methyltransferases

Growing community of inventors

Berlin, Germany

Christian Dalhoff