Millennium Pharmaceuticals Limited

Infinity Pharmaceuticals, Inc.

Millenium Pharmaceuticals, Inc.

Infinity Discovery, Inc.

Christian C Fritz

Philip Youngman

Luz-Maria Guzman

Alfredo C Castro

Michael J Grogan

Edward Holson

Tao Liu

Daniel A Snyder

Brian T Hopkins

Dennis John Underwood

Michael Andrew Foley

Asimina T Georges Evangelinos

Wei Deng

Nii O Koney

Lin-Chen Yu

Linping Zhang

Christopher Murphy

David A Mann

Kristopher M Depew

Lisa A Marcaurelle

Andrew A Wylie

Nafeeza Hafeez

Michael A Foley

Edward B Holson

One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.

Compounds and methods for inhibiting the interaction of BCL proteins with binding partners

Disclosed are genes found inthat are essential for survival for a wide range of bacteria. These genes are termed 'S-ylqF,' 'S-yqeG,' &#x201c;S-yybQ,&#x201d; &#x201c;S-yerL,&#x201d; and &#x201c;S-ysxC.&#x201d; These genes and the polypeptides that they encode, as well as homologs and orthologs thereof can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

Use of ylqF, yqeG, yybQ, and ysxC, essential bacterial genes and polypeptides

Disclosed is a gene, termed 'S-yneS,' found in, which is essential for survival for a wide range of bacteria. This gene and the S-yneS polypeptide that it encodes, as well as homologs and orthologs thereof (collectively referred to as 'yneS' genes and polypeptides) can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

Use of yneS, essential bacterial genes and polypeptides

Disclosed are genes found in that are essential for survival for a wide range of bacteria. These genes are termed &ldquo;S-ylqF,&rdquo; &ldquo;S-yqeG,&rdquo; &ldquo;S-yybQ,&rdquo; &ldquo;S-yerL,&rdquo; and &ldquo;S-ysxC.&rdquo; These genes and the polypeptides that they encode, as well as homologs and orthologs thereof can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

Disclosed are two genes, termed &ldquo;yphC&rdquo; and &ldquo;yqjK,&rdquo; found in , which are essential for survival for a wide range of bacteria. These genes and the essential polypeptides that they encode, as well as homologs and orthologs thereof, can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

Essential bacterial genes and their use

Disclosed are genes, termed &ldquo;yacM&rdquo; and &ldquo;yqeJ,&rdquo; which are essential for survival for a wide range of bacteria, such as and These genes and the essential polypeptides they encode can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

Use of yacM and yqeJ, essential bacterial genes and polypeptides and their use

Use of YLQF, YQEG, YYBQ, and YSXC, essential bacterial genes and polypeptides

Disclosed are methods for using the essential genes and polypeptides &ldquo;S-ydcB,&rdquo; found in , and &ldquo;B-ydcB,&rdquo; found in . These genes and polypeptides, as well as homologs and orthologs thereof, can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

Use of S-ydcB and B-ydcB, essential bacterial genes

Disclosed is a gene, termed &ldquo;S-yneS,&rdquo; found in , which is essential for survival for a wide range of bacteria. This gene and the S-yneS polypeptide that it encodes, as well as homologs and orthologs thereof (collectively referred to as &ldquo;yneS&rdquo; genes and polypeptides) can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

Use of YNES, essential bacterial genes and polypeptides

Disclosed are 23 genes, termed &ldquo;GEP&rdquo; genes, found in , which are located within operons that are essential for survival. Also disclosed is a related essential gene found in . These genes and the polypeptides that they encode, as well as homologs thereof, can be used to identify antibacterial agents for treating bacterial infections such as streptococcal pneumonia.

Growing community of inventors

Natick, MA, United States of America

Christian C Fritz