Exelixis, Inc.

Christian Burks

John William Winslow

Helen Louise Francis-Lang

Darren Platt

Bindu Priya Reddy

Yuling Luo

Andrew Roy Buchman

Candace Swimmer

Casey Kopczynski

Jonathan Cagampang Heller

Jonathan Scott Margolis

Lucile A Gillett

Tandem pore domain weak inward rectifying K (TWIK) channel nucleic acids and proteins that have been isolated from and Leptinotarsa are described. The TWIK channel nucleic acids and proteins can be used to genetically modify metazoan invertebrate organisms, such as insects, coelomates, and pseudocoelomates, or cultured cells, resulting in TWIK channel expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential pesticidal agents or therapeutics that interact with TWIK channel proteins. They can also be used in methods for studying TWIK channel activity and identifying other genes that modulate the function of, or interact with, the TWIK channel gene.

Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use

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Berkeley, CA, United States of America

Christian Burks