Sterix Limited

Christian Bubert

Atul Purohit

Michael John Reed

Barry Victor Lloyd Potter

Lok Wai Lawrence Woo

Oliver Brook Sutcliffe

Toby Jackson

Nigel Vicker

Paul Michael Wood

Harshani Rithma Ruchiranani Lawrence

Gillian Margaret Allan

Delphine Sophie Marion Fischer

Aurélien Putey

Barry Victory Lloyd Potter

There is provided a compound of formula I  wherein t is 1 or 2wherein R'is a unsubstituted or substituted phenyl group;wherein each of Rto Ris independently selected from &#x2014;H, NO, halo, &#x2014;O&#x2014;(C-C)haloalkyl, (C-C)haloalkyl, (C-C)alkyl, &#x2014;CN, &#x2014;OH, &#x2014;OPh, &#x2014;OBn, -Ph, &#x2014;OSONRR, &#x2014;SOR, &#x2014;SONRR, &#x2014;O&#x2014;(C-C)alkyl, &#x2014;(C&#x2550;O)NRRand &#x2014;CO(O)R;

Compound

There is provided a compound of Formula I wherein X, Y and Z are each independently of each other an optional linker group; Ris a ring system; Ris selected from hydrocarbyl groups, oxyhydrocarbyl groups, cyano (&#x2014;CN), nitro (&#x2014;NO) and halogens; Rand Rare independently selected from H and hydrocarbyl, ring A and B are independently optionally further substituted.

Phenyl-sulfamates as aromatase inhibitors

There is provided a compound of Formula (III) wherein

17B-hydroxysteroid dehydrogenase inhibitors

There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, &#x2014;F&#x2014;R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CHand C&#x2550;O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.

Polycyclic sulphamate compounds suitable for use as inhibitors of aromatase and/or sulphatase

There is provided a compound of Formula Iwherein each T is independently selected from H, hydrocarbyl, &#x2014;F&#x2014;R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CHand C&#x2550;O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.

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Christian Bubert