Novartis Ag

Christian Bruns

Rainer Albert

Gisbert Weckbecker

Wilfried Bauer

Ian Lewis

Bernhard Wietfeld

David Bodmer

Mark Meisenbach

Heribert Hellstern

Ivo Felner

Peter Smith-Jones

Barbara Stolz

Gebhard Thoma

Nigel Graham Cooke

Markus Streiff

Hans-Günter Zerwes

Nagarajan Chandramouli

François Nuninger

The invention provides cyclo[{4-(NH&#x2014;CH&#x2014;NH&#x2014;CO&#x2014;O&#x2014;)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.

Somatostatin analogues

The invention provides cyclo[{4-(NH&#x2014;CH&#x2014;NH&#x2014;CO&#x2014;O-)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.

Disclosed are compounds of formula I: wherein R, R, Rand X are as defined herein, in free or salt form, which are useful as CCR5 inhibitors, e.g. in the prevention or treatment of disorders mediated by interactions between chemokine receptors and their ligands.

Piperidine derivatives as CCR5 inhibitors

Peptides

Somatostain analogues comprising the amino acid sequence of the formula (I): -(D/L)Trp-Lys-X,-X,, wherein X,is a substituted Thr, Ser, Tyr, Glu or Cys residue and X,is an &agr;-amino acid having an aromatic residue on the C,side chain, or an amino acid unit selected from Dab, Dpr, Dpm, His (Bzl)HyPro, thienyl-Ala, cyclohexyl-Ala and t.-butyl-Ala, the residue Lys of said sequence corresponding to the residue Lys,of the native somatostatin-14, in free form, in salt form or complexed with a detectable element have interesting pharmacological properties.

Somatostatin peptides

Chelated peptides, complexes thereof, pharmaceutical compositions containing them and their use as radiopharmaceuticals

Growing community of inventors

Freiburg, Germany

Christian Bruns