Basf Plant Science Company Gmbh

Sungene Gmbh & Co. Kgaa

Sungene Gmbh & Co. Kgaa and Institut F. Pflanzengenetik U. Kulturpflanzenforschung

Sungene Gmbh

Institut F. Pflanzengenetik

Christian Biesgen

Holger Puchta

Andrea Hlubek

Hans Wolfgang Höffken

Hans Wolfgang Hoeffken

Friedrich Fauser

Michael Pacher

Rocio Sanchez-Fernandez

Nadine Roth

The present invention relates to methods to modify at least one target locus in a plant cell, comprising, providing a plant cell with one or more target loci and one or more donor loci, followed by induction of homologous recombination between homologous regions of at least one target locus and at least one donor locus by at least one rare cleaving nuclease. The present invention related also to target loci, donor loci and nuclease loci used in these methods, and plant cells, plants and plant parts comprising these target loci, donor loci, nuclease loci and/or the recombined loci.

In planta recombination

The invention relates to chimeric endonucleases, comprising a endonuclease and a heterologous DNA binding domain comprising one or more ZnCzinc fingers, as well as methods of targeted integration, targeted deletion or targeted mutation of polynucleotides using chimeric endonucleases.

Chimeric endonucleases and uses thereof

Provided are optimized endonucleases, as well as methods of targeted integration, targeted deletion or targeted mutation of [polynucleotides using optimized endonucleases.

Optimized endonucleases and uses thereof

The invention relates to recombination systems and methods for eliminating nucleic acid sequences from the chromosomal DNA of eukaryotic organisms, and to transgenic organisms&#x2014;preferably plants&#x2014;which comprise these systems or were generated using these methods.

Recombination systems and methods for eliminating nucleic acid sequences from the genome of eukaryotic organisms

The present invention relates to novel methods for the generation of transgenic plants with genetically modified plastids, and to the transgenic plants generated with these methods.

Growing community of inventors

Quedlinburg, Germany

Christian Biesgen