Centre National De La Recherche Scientifique

Christian Bergaud

Matthieu Guirardel

Pascal Belaubre

Albert Claude Boccara

Azzedine Bousseksou

Jean-Bernard Pourciel

Benoît Belier

Augustin Martinez

Marie-Claude Potier

Jean-Paul Roger

Benoit Belier

Lionel Salmon

Gabor Molnar

Nicu Livus

Emeline Cocheteau

Benoît Résidence d'Ilôt Des Cours Belier

The invention relates to a device for the actively-controlled deposition of microdrops of biological solutions. The inventive device includes at least one flat silicon lever comprising a central body and an end area which forms a point, a slit or groove being disposed in said point. The invention is characterized in that it also comprises at least one metallic track which is disposed on one face of the central body and which runs alongside said slit or groove at least partially. The invention also relates to a method of producing the inventive device and a method for the active-controlled deposition and sampling of microdrops of biological solutions using said device.

Device for the actively-controlled and localized deposition of at least one biological solution

The invention relates to a device for the actively-controlled deposition of microdrops of biological solutions. The inventive device consists of at least one flat silicon lever comprising a central body and an end area which forms a point, a slit or groove being disposed in said point. The invention is characterized in that it also comprises at least one metallic track which is disposed on one face of the central body and which runs alongside said slit or groove at least partially. The invention also relates to a method of producing the inventive device and a method for the active-controlled deposition and sampling of microdrops of biological solutions using said device.

Device for the actively-controlled and localised deposition of at least one biological solution

The invention concerns an apparatus for parallel detection of the behaviour of mechanical micro-oscillators interacting with the sample (). The amplitude and the phase of resonance of micro-oscillators () are measured with optical means. The invention is characterised in that a source () is active during a fraction 1/n of the period (n being an integer) and of variable phase p/n of the period (p being an integer). Interferences are produced between light beams generated by reflection of incident light beams () and () on the micro-oscillators (). Periodically the micro-oscillators () are displaced by means. The value of the parameter p (p being an integer) is varied and N elementary measurements are integrated to obtain a measurement representing each of the values of p. The phase and amplitude of each micro-oscillator () are calculated on the basis of the representative data obtained for each value of p and this for a large number of accumulations. The invention is applicable in the field of nanotechnologies.

Apparatus for parallel detection of the behaviour of mechanical micro-oscillators

The invention relates to a biosensor matrix comprising a substrate made of semiconductor material. It has a main plane surface and cavities formed in a surface opposite from said plane surface to define between the bottoms of said cavities and the main plane surface deformable structure each including at least one piezoresistive or piezoelectric sensing element. The method of manufacture implements fabrication techniques specific to micro- and nanotechnologies, preferably with localized pre-amorphization of the surface of the substrate prior to implantation of piezoelectric elements, which implantation is followed by annealing.

Biosensor matrix and method for making same

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Toulouse, France

Christian Bergaud