Electrophoretics Limited

Other

Christian Baumann

Malcolm Andrew Ward

Karsten Kuhn

Stefan Kienle

Helen Louise Byers

Peter Schulz-Knappe

Richard Joubert

Juergen Schaefer

Simon Lovestone

Jules Westbrook

Abdul Hye

Petra Prefot

Harald Legner

Stephen Lynham

Thorsten Prinz

The disclosure provides a method for assaying for a target analyte, comprising providing a plurality of samples which may comprise the target analyte, wherein each sample is differentially labelled with a mass label or a combination of mass labels, wherein the mass labels are from a set of mass labels, wherein each mass label is an isobaric mass label comprising a mass spectrometrically distinct mass marker group, such that the samples can be distinguished by mass spectrometry and determining from the mass spectrum the quantity of the target analyte in each sample.

Mass spectrometric analysis

A reactive mass label for labelling a biological molecule for detection by mass spectrometry, which label comprises a reactive functionality for labelling thiol groups or carbonyl groups. Also provided is a reactive mass label for labelling a biological molecule for detection by mass spectrometry, wherein the mass label comprises the following structure:X-L-M-S&#x2014;Rewherein X is a mass marker moiety, L is a cleavable linker, M is a mass normalization moiety, S is a mass series modifying group comprising the following group: wherein J is C&#x2550;O, K is NH, and n is 2 or J and K are both CHand n is 1, and wherein m is at least 1; and Re is a reactive functionality for attaching the mass label to a biological molecule.

Mass labels

Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.

Methods of diagnosing Alzheimer's disease

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Darmstadt, Germany

Christian Baumann