Psivida US, Inc.

Eyepoint Pharmaceuticas, Inc.

Psimedica Limited

Eyepoint Pharmaceuticals, Inc.

Eyepoint Pharmaceuticals US, Inc.

Psivida Inc.

Christian Barnett

Leigh Trevor Canham

Paul Ashton

Hong Guo

Martin Nazzaro

This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.

Bioerodible silicon-based devices for delivery of therapeutic agents

The invention comprises a composition comprising a bioerodible porous silicon-based carrier material wherein the carrier material carries at least one large molecule therapeutic agent and at least one amorphous sugar, optionally further comprising a crystallization inhibitor. The composition may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The composition may be used for treating or preventing conditions of a patient such as chronic diseases.

Bioerodible silicon-based compositions for delivery of therapeutic agents

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Pershore, United Kingdom

Christian Barnett