Centre National De La Recherche Scientifique

Bionoox Suisse Sa

Ecole Normale Superieure De Cachan

Other

Medizinische Universitat Wien

Bioalliance Pharma

Ens Cachan

Paris-sud, Universite

Ac Bioscience

Ac Bioscience Sa

Christian Auclair

Frédéric Subra

Peter Valent

Didier Desmaele

Jean D'Angelo

Esther Fellous

Patrice Le Pape

Jean-Francois Mouscadet

Valérie Polard

Ghaith Wedeh

Odile Cohen-Haguenauer

Rosine Saleh

Christelle Pragnon

Michel Arock

Jorge E Kalil-Filho

Khalid Mekouar

Fr&egrave;d&egrave;ric Subra

Annette Ives

The use of a neoadjuvant prior to chemotherapy. A sphingosine-1-phosphate pathway activator for use in the treatment of cancer as a neoadjuvant prior to chemotherapy selected from sphingosine-1-phosphate lyase inhibitors. The sphingosine-1-phosphate pathway activator enhances the chemotherapy efficiency through the normalization of intratumoral vascular network, promoting the effects of the sequential administration of an anticancer agent or a sequential radiotherapy.

Enhancement of cancer treatment efficiency via the sphingosine-1-phosphate pathway

The present invention relates to a composition comprising a combination of a (halogenoacetamido)benzoate, a flavonol and a terpene, and, as example, relates to a composition comprising the combination of ethyl 3-(2-chloroacetamido)benzoate, dihydroquercetin and bisabolol. Said composition is for use in the treatment of leishmaniasis, especially cutaneous or mucosal leishmaniasis, the composition being applied topically for concomitantly treating both parasitic infection and skin inflammation of the infected area induced by leishmaniasis.

Topical compositions for the treatment of cutaneous leishmaniasis

Disclosed is the use of a composition including dihydroquercetin and optionally &#x3b1;-tocopherol and/or bisabolol for treating herpes infection. Also disclosed is the use of such a composition for treating inflammation induced by herpes infection in mucosa, as well as a method for treating HSV infection and the associated inflammation.

Compositions comprising dihydroquercetin for use in methods for treating herpes

The present invention relates to a human mast cell line corresponding to deposit number CNCM I-4551 and also to the lines derived therefrom, in particular the derived lines corresponding respectively to deposit numbers CNCM I-4552 and CNCM I-4553, and to the uses thereof, in particular for screening for compounds of therapeutic interest.

Human mast cell lines, preparation and uses

A method of using a composition including dihydroquercetin, as well as optionally &#x3b1;-tocopherol and/or bisabolol, for treating the effects associated with skin inflammatory disorder, such as those associated with diseases characterized by inappropriate immune response, such as psoriasis, atopic dermatitis and/or urticaria. A process of manufacturing the composition is also described.

Compositions comprising dihydroquercetin for use in methods for treating the effects associated with skin inflammatory disorders

A composition includes dihydroquercetin, &#x3b1;-tocopherol and bisabolol. The use of the composition in a cosmetic method for limiting, alleviating and/or preventing cutaneous discomfort, especially cutaneous discomfort induced by a disease or induced by a therapy, a radiotherapy treatment and/or chemotherapy treatment, and the process of manufacturing the composition are also described.

Companion cosmetic compositions

The present invention relates to a gene transfer vector (GTV) and in particular to an integrating gene transfer vector (IGTV), which comprises at least one genetic insulator element (GIE), wherein the each comprises at least two copies of an element selected from the group consisting of: a CTF binding site; a first CTCF binding site and a second CTCF binding site, wherein the first and the second CTCF binding sites are derived from the regulatory sequences of different genes.

Gene transfer vectors comprising genetic insulator elements and methods to identify genetic insulator elements

The present invention relates to a method for treating proliferative mastocytosis comprising administering a Bruton tyrosine kinase (BTK) inhibitor, a BTK antisense to a mammal in need of such treatment. The invention is more particularly suited for treating category II, III and IV mastocytosis.

Use of inhibitors and antisense oligonucleotides of BTK for treating proliferative mastocytosis

The invention concerns a method for analyzing tumor agressivity of cancer cells comprising measurement of the amount of stationary polymerized actin in a lysate of said cells. Advantageously, the measurement of the amount of stationary actin is carried out by fluorescence static polarization.

Method for analyzing tumor aggressivity comprising measurement of polymerized actin

The invention concerns quinoline derivatives of formula (I) in which: R , R and R , identical or different represent one or several substituents, themselves identical or different, in any position on the cycles, this or these substituents being selected among a &mdash;(CH ) &mdash;Y or &mdash;CH&boxH;CH&mdash;Y group, in which Y is halogen, &mdash;OH, &mdash;OR, &mdash;COH, &mdash;COR, &mdash;COOH, COOR, &mdash;COH, &mdash;COR, &mdash;CONH , &mdash;CON(R , R )&mdash;CH&boxH;NOH, &mdash;CO&mdash; &mdash;CH&boxH;NOH, &mdash;NH , &mdash;N(R , R ), &mdash;NO , &mdash;PO(OR) &mdash;SH , &mdash;SR, &mdash;SO R, &mdash;SO NHR, CN, or Z(R ) in which R is a C1-C8 alkyl, or aryl or a heterocyclic compound, R and R , identical or different are C1-C5 alkyl, an aryl or heterocyclic compound and n is nil or a whole number between 1 and 5 R can further represent a hydrogen, and when Y is &mdash;COOH or &mdash;COOR in R , Z, if it represents an aryl, comprises at least 3 substituents or the quinoline ring is trisubstituted; X is an ethylene double bond; a &mdash;(CH ) &mdash; group in which n is a whole number between 1 and 5: or a &mdash;CH(R &mdash;CH(R ) group, R and R , identical or different, representing a hydrogen, a halogen, hydroxy or epoxy; or a &mdash;(CH ) , &mdash;O&mdash;C&mdash;(CH ) &mdash;, &mdash;(CH ) , &mdash;C(O)&mdash;O&mdash;(CH ) , &mdash;(CH ) , &mdash;O&mdash;(CH ) &mdash;, (CH ) , &mdash;N(Q)&mdash;(CH ) &mdash;, or (CH ) , &mdash;S(O)&mdash;(CH ) &mdash;, group, in which n&equals;1 to 8, m&equals;0 to 8, t&equals;0, 1 or 2, and Q&equals;h, aryl or alkyl. The invention also concerns the pharmaceutically acceptable salts of these derivatives, the diastereoisomeric and the enantiomeric forms thereof. The invention is useful as medicines with HIV anti-integrase inhibiting effect.

Growing community of inventors

Paris, France

Christian Auclair