International Business Machines Corporation

Acelot, Inc.

Armonk Business Machines Corporation

Christian Alexander Lang

Ioana Roxana Stanoi

Bishwaranjan Bhattacharjee

Timothy Ray Malkemus

Yuan-Chi Chang

George Andrei Mihaila

Lipyeow Lim

Jun-Jang Jeng

Ambuj Kumar Singh

John Richard Smith

Sriram Kolinjivadi Padmanabhan

Min Wang

Themis Palpanas

Kwai Wong

Ching-Yung Lin

Mustafa Canim

Lawrence H Koved

Belle L Tseng

Kenneth Andrew Ross

Hung-Yang Chang

Igor Sominsky

The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of certain types of oligomers in a subject. More specifically, the drugs and compositions reduce or prevent the formation of oligomers formed from tau protein, TDP-43, Huntingtin's protein and/or alpha-synuclein. It further provides a method of reducing formation of or disrupting TDP-43, alpha-synuclein, Huntingtin's protein and/or tau protein oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.

Small molecule drugs and related methods for treatment of diseases related to TDP-43, alpha-synuclein, huntingtin's protein and tau protein oligomer formation

Described herein, inter alia, are certain substituted piperazines, for example, having the Formula 182, and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of Aβ42 oligomers in a subject. It further provides a method of reducing formation of or disrupting Aβ42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.

Substituted piperazines as disrupters of AB42 oligomer formation

The present disclosure provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of A&#x3b2;42 oligomers in a subject. It further provides a method of reducing formation of or disrupting A&#x3b2;42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition. One such compound is a compound of formula 120:

Substituted amines as disrupters of ABETA42 oligomer formation

The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of A&#x3b2;42 oligomers in a subject. It further provides a method of reducing formation of or disrupting A&#x3b2;42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.

Small molecule drugs and related methods for treatment of diseases related to A&#x3b2;42 oligomer formation

A method is provided for compressing results of a join query. A join order of a result set is determined from the join query, where the result set includes a plurality of tuples. A plurality of dictionary entries for the result set is received. A nested hierarchy of dictionaries is created based on the join order and the dictionary entries. A plurality of encoded tuples is received. The nested hierarchy of dictionaries is used by a processor to decode the plurality of encoded tuples so as to produce the plurality of tuples of the result set.

Query-aware compression of join results

Techniques are disclosed for multi-granularity hierarchical aggregate selection based on update, storage and response constraints. For example, for a temporal hierarchy of aggregation statistics associated with a plurality of database records, wherein the temporal hierarchy comprises two or more aggregation statistics levels and each level has a different temporal granularity associated therewith, a method comprises iteratively modifying the temporal hierarchy to at least one of: (a) minimize a storage usage cost while satisfying a temporal hierarchy update constraint and a query response time constraint; (b) reduce a temporal hierarchy update time and a query response time while satisfying a storage usage constraint; and (c) minimize a query response time for frequently applied queries that do not shift in time while satisfying the storage usage constraint, wherein the resulting temporal hierarchy that achieves at least one of (a), (b) and (c) is identified as an optimal temporal hierarchy.

Multi-granularity hierarchical aggregate selection based on update, storage and response constraints

A method is provided for compressing results of a join query. A join order of a result set comprising multiple tuples is determined from the join query, and a nested hierarchy of dictionaries is maintained based on the join order. The nested hierarchy of dictionaries is used to encode each of the tuples of the result set so as to produce an encode tuple, and each of the encoded tuples is transmitted to a client system. Also provided is a method for decompressing results of a join query.

A system, method, and computer readable medium for reducing message flow on a message bus are disclosed. The method includes determining if at least one logical operator in a plurality of logical operators requires processing on a given physical processing node in a group of physical nodes. The logical operator is pinned to the given physical processing node. The pinning prevents any subsequent reassignment of the logical operator to another physical processing node. Each logical operator in the plurality of logical operators is assigned to an initial physical processing node in the group of physical processing nodes on a message bus. A determination is made as to whether at least one logical operating in the plurality of logical operators needs to be reassigned to a different physical processing node. The at least one logical operator is reassigned to the different physical processing node.

Reduction of message flow between bus-connected consumers and producers

A system, method, and computer readable medium for reducing message flow on a message bus are disclosed. The method includes determining if at least one logical operator in a plurality of logical operators requires processing on a given physical processing node in a group of physical nodes. In response to determining that the logical operator requires processing on the given physical processing node, the logical operator is pinned to the given physical processing node. Each logical operator in the plurality of logical operators is assigned to an initial physical processing node in the group of physical processing nodes on a message bus.

Providing consistency guarantees in a data stream processing engine is provided. Consistency tracking information is attached to data streams coming into the data stream processing engine. The consistency tracking information is propagated through a plurality of streaming operators that process the data streams within the data stream processing engine. Then, the propagated consistency tracking information is used to detect a consistent state in an output stream.

Providing consistency in processing data streams

An index scan processor and method to perform concurrent scans of stored indexed data. An indexed data scanner performs a first scan of stored data by sequentially scanning through an index data structure and maintains, over a duration of the first scan, a first scan current scan location within the index data structure that indicates a currently accessed record within the stored data structure for the first scan. A scan manager accepts a request for a second scan of the stored data, determines, during the performing the first scan, a starting index scan location within the index data structure for the second scan that is sufficiently near the first scan current index scan location to cause records indicated by the starting location index to be stored within a buffer due to the performing the first scan, and starts the second scan at the starting location and proceeding to the second end key.

System and method for executing multiple concurrent index-driven table access operations

Techniques are provided for enabling execution of a process employing a cache Method steps can include obtaining a first probability of accessing a given artifact in a state S, obtaining a second probability of using a predicate from a current state Sin the state S, determining a benefit of prefetching the given artifact using the predicate based on at least the first probability and the second probability, and whether and/or when a cache replacement should be conducted, based at least on the benefit determined.

Method and apparatus for execution of a process

A system and method for managing a cache includes monitoring a temperature of regions on a secondary storage based on a cumulative cost to access pages from each region of the secondary storage. Similar temperature pages are grouped in logical blocks. Data is written to a cache in a logical block granularity by overwriting cooler blocks with hotter blocks.

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New York, NY, United States of America

Christian Alexander Lang