Abbott Laboratories Corporation

Christi Powell Scheffel

Edward N Granados

Julian D Gordon

Stephen D Stroupe

John C Russell

Tracey L Colpitts

Maurice Cohen

Michael R Klass

Paula N Friedman

Patricia A Billing-Medel

Steven C Hodges

Jon D Kratochvil

A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BU101 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

Reagents and methods useful for detecting diseases of the breast

Nucleic acid sequences are provided that are useful as amplification primers and hybridization probes for detecting CK19 target sequence in a test sample. The primers and probes can be employed in amplification based methods for detecting the presence of CK19 sequences in a test sample. The amplification product can be detected with the assistance of microparticle capture techniques.

Nucleic acid primers and probes for detecting tumor cells

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Mundelein, IL, United States of America

Christi Powell Scheffel