Morphosys Ag

F. Hoffmann-La Roche Ag

Hoffmann-La Roche Inc.

Christer Nordstedt

Christine Rothe

Michael Otto Bardroff

Bernd Bohrmann

Walter Huber

Manfred Brockhaus

Hansruedi Loetscher

Titus Kretzschmar

Corinna Löhning

The present invention relates to antibody molecules capable of specifically recognizing two regions of the &#x3b2;-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.

Nucleic acid molecules encoding anti-amyloid beta antibodies

Anti-A&#x3b2; antibodies and their use

The present invention relates to antibody molecules capable of specifically recognizing two regions of the R-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.

Anti-amyloid &#x3b2; antibodies

Growing community of inventors

Sodertalje, Sweden

Christer Nordstedt