Lts Lohmann Therapie-systeme Gmbh + Co. Kg

Lts Lohmann Therapie-systeme Ag

Christa Nalbach

Hans-Rainer Hoffmann

Walter Muller

Walter Mueller

Rainer Hoffmann

Gunter Simon

Karin Wolter

The invention relates to a patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature which comprises a multi-element system comprising (a) a matrix having distributed therein as the drug said volatile active ingredient or a physiologically acceptable salt thereof, the matrix comprising a pressure-sensitive adhesive, (b) an element of a pressure-sensitive adhesive composition which--where (a) contains a salt--contains basic groups to liberate the free base from its salt, (c) a backing layer impermeable to the diffusable ingredients of (a) and (b), and (d) a release liner impermeable to the diffusable ingredients of (a) and (b), matrix (a) or at least a part of (b), whichever is in contact with release liner (d), having a tack sufficient for affixing the patch to the skin, any part of (b) positioned between matrix (a) and release liner (d) being permeable for the deprenyl or the salt thereof or both. The invention also relates to a process for preparing such patch and to a process for treating a patient suffering from Parkinson's or Alzheimer's disease with such patch.

Patch for transdermal administration of volatile pharmaceutically active

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Leutesdorf, Germany

Christa Nalbach