Hoffmann-La Roche Inc.

Chrisitan Lerner

Philippe Pflieger

Daniel Hunziker

Ulrike Obst Sander

Werner Mueller

Pius Waldmeier

The present invention relates to compounds of formula I wherein Rto R, R, Rand Rare as defined in the description and claims and Rsignifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

2,3-diaryl- or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds

The present invention relates to compounds of formula I wherein R.sup.1a to R.sup.1e and R.sup.2 to R.sup.5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

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Binningen, Switzerland

Chrisitan Lerner