Cornell Research Foundation Inc.

Cornell University

Other

Ofs Fitel, LLC

Chris Xu

Watt W Webb

Lars Gruner-Nielsen

Dan Peter Jakobsen

James Van Howe

Martin E V Pedersen

Ji Cheng

Kriti Charan

Michael Buttolph

Bo Li

Amit Lal

Alexander Gaeta

Ankur Singh

Jennifer Lee

Jay E Sharping

Fei Xia

David Sinefeld

Martin Ev Pedersen

An integrated GHz ultrasonic neuro-cognitive system including a chip-cyborg having a network of biological neurons that forms a biological information processor, which can be controlled by electronics, optics, and GHz ultrasonic beams. In one example, the chip-scale microsystem includes a CMOS chip with RF CMOS and piezoelectric thin film transducers that can generate GHz ultrasonic waves, which can be phased to form narrow beams, achieving significant ultrasonic intensity to affect neurons. With a sufficient number of ultrasonic pixels, the focal point of the beam can be narrow enough to focus effect specific section of a neuron to enhance or decrease synaptic weights owing to ultrasonic radiation forces and acoustic streaming.

GHz-THz ultrasonics and optics for neurotechnology devices, methods, and applications

A system and method for adaptive illumination, the imaging system comprising an excitation source having a modulator, which generates a pulse intensity pattern having a first wavelength when the excitation source receives a modulation pattern. The modulation pattern is a data sequence of a structural image of a sample. An amplifier of the imaging system is configured to receive and amplify the pulse intensity pattern from the modulator. A frequency shift mechanism of the imaging system shifts the first wavelength of the pulse intensity pattern to a second wavelength. A laser scanning microscope of the imaging system receives the pulse intensity pattern having the second wavelength.

Adaptive illumination apparatus, method, and applications

Embodiments of the present invention generally relate to fiber designs for wavelength tunable ultra-short pulse lasers. More specifically, embodiments of the present invention relate to systems incorporating fiber designs for higher order mode fibers capable of soliton self frequency shifting where a system comprises a first fiber for shifting the wavelength from a pump wavelength to a transfer wavelength and a second fiber for shifting the pulse from the transfer wavelength to an output wavelength. In one embodiment of the present invention, a wavelength tunable short pulse fiber laser system comprises: a pulse generator for providing a pulse having an input wavelength; a mode-converter; a first designed fiber for shifting the pulse from the input wavelength to a transfer wavelength; and a second designed fiber for shifting the pulse from the transfer wavelength to an output wavelength.

Fiber designs for wavelength tunable ultra-short pulse lasers

Embodiments of the present invention generally relate to optical mode conversion by nonlinear effects. More specifically, embodiments of the present invention relate to nonlinear mode conversion utilizing intermodal four-wave mixing to convert light between modes having different wavelengths for complex applications. In one embodiment of the present invention, a fiber comprises an input end for receiving light in a first mode at a first wavelength, and an output end for outputting light in a desired second mode at a desired second wavelength, wherein the first wavelength and the second wavelength are not the same. In many embodiments, the fiber comprises a higher-order mode fiber.

Optical mode conversion by nonlinear effects

The present invention relates to an apparatus for producing optical pulses of a desired wavelength. The apparatus includes an optical pulse source operable to generate input optical pulses at a first wavelength. The apparatus further includes a higher order mode (HOM) fiber module operable to receive the input optical pulses at the first wavelength, and thereafter to produce output optical pulses at the desired wavelength by soliton self-frequency shift (SSFS). The present invention also relates to a method of producing optical pulses having a desired wavelength. This method includes generating input optical pulses using an optical pulse source, where the input optical pulses have a first wavelength and a first spatial mode. The input optical pulses are delivered into an HOM fiber module to alter the wavelength of the input optical pulses from the first wavelength to a desired wavelength by soliton self-frequency shift (SSFS) within the HOM fiber module, thereby producing output optical pulses having the desired wavelength.

Production of optical pulses at a desired wavelength using soliton self-frequency shift

Embodiments of the invention include an optical system and an optical system module, coupled to a distal end of a fluorescence emission endoscope apparatus, an optical waveguide-based fluorescence emission endoscopy system, and a method for remotely-controlled, multi-magnification imaging of a target or fluorescence emission collection from a target with a fluorescence emission endoscope apparatus. An exemplary system includes an objective lens disposed in a distal end of an endoscope apparatus. The lens is adapted to transmit both a visible target illumination and a fluorescence-emission-inducing target illumination as well as fluorescence-emission and visible light from the target. The system can thus simultaneously provide low magnification, large field of view imaging and high magnification, high-resolution multiphoton imaging with a single lens system.

Multi-path, multi-magnification, non-confocal fluorescence emission endoscopy apparatus and methods

The present invention relates to an apparatus for producing optical pulses of a desired wavelength. The apparatus includes an optical pulse source operable to generate input optical pulses at a first wavelength. The apparatus further includes a higher-order-mode (HOM) fiber module operable to receive the input optical pulses at the first wavelength, and thereafter to produce output optical pulses at the desired wavelength by soliton self-frequency shift (SSFS). The present invention also relates to a method of producing optical pulses having a desired wavelength. This method includes generating input optical pulses using an optical pulse source, where the input optical pulses have a first wavelength and a first spatial mode. The input optical pulses are delivered into an HOM fiber module to alter the wavelength of the input optical pulses from the first wavelength to a desired wavelength by soliton self-frequency shift (SSFS) within the HOM fiber module, thereby producing output optical pulses having the desired wavelength.

Production of optical pulses at a desired wavelength using soliton self-frequency shift in higher-order-mode fiber

A technique for generating variable pulse delays uses one or more nonlinear-optical processes such as cross-phase modulation, cross-gain modulation, self-phase modulation, four-wave mixing or parametric mixing, combined with group-velocity dispersion. The delay is controllable by changing the wavelength and/or power of a control laser. The delay is generated by introducing a controllable wavelength shift to a pulse of light, propagating the pulse through a material or an optical component that generates a wavelength dependent time delay, and wavelength shifting again to return the pulse to its original wavelength.

All-optical, continuously tunable, pulse delay generator using wavelength conversion and dispersion

A method and apparatus for generating a multi-wavelength pulse train use a technique referred to as time-lens compression. The time-lens is formed of a phase modulator in series with a dispersion element. In addition to pulse compression, this time-lens simultaneously displaces the pulses according to their center wavelengths, resulting in a temporally evenly spaced multi-wavelength pulse train. An aberration correction technique, based on the temporal analog of a spatial correction lens, can also be employed improve the quality of the compressed pulses. Through use of CW DFB lasers and electrooptic phase modulators, the all-fiber system allows complete tunability of temporal spacing, spectral profile and repetition rate.

Multi-wavelength pulse generator using time-lens compression

A laser scanning microscope produces molecular excitation in a target material by simultaneous absorption of three or more photons to thereby provide intrinsic three-dimensional resolution. Fluorophores having single photon absorption in the short (ultraviolet or visible) wavelength range are excited by a beam of strongly focused subpicosecond pulses of laser light of relatively long (red or infrared) wavelength range. The fluorophores absorb at about one third, one fourth or even smaller fraction of the laser wavelength to produce fluorescent images of living cells and other microscopic objects. The fluorescent emission from the fluorophores increases cubicly, quarticly or even higher power law with the excitation intensity so that by focusing the laser light, fluorescence as well as photobleaching are confined to the vicinity of the focal plane. This feature provides depth of field resolution comparable to that produced by confocal laser scanning microscopes, and in addition reduces photobleaching and phototoxicity. Scanning of the laser beam by a laser scanning microscope, allows construction of images by collecting multi-photon excited fluorescence from each point in the scanned object while still satisfying the requirement for very high excitation intensity obtained by focusing the laser beam and by pulse time compressing the beam. The focused pulses also provide three-dimensional spatially resolved photochemistry which is particularly useful in photolytic release of caged effector molecules, marking a recording medium or in laser ablation or microsurgery. This invention refers explicitly to extensions of two-photon excitation where more than two photons are absorbed per excitation in this nonlinear microscopy.

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Ithaca, NY, United States of America

Chris Xu