Mcneil Ab

Mcneil Laboratories, Incorporated

Ortho Pharmaceutical Corporation

Chris R Rasmussen

Henry Joseph Breslin

Robert E Boyd

Michael Joseph Kukla

Robert W Tuman

Joseph F Gardocki

Jeffrey Bruce Press

James N Plampin

Malcolm K Scott

Frank J Villani, Jr

Described herein are 4-�(thien-3-yl)methyl!-imidazoles of the formula: ##STR1## wherein R is hydrogen or methyl, and

4-�(thien-3-yl)methyl!-imidazole analgesics

The 4-[(thien-2-yl)methyl]-imidazoles of the formulae: ##STR1## wherein R is hydrogen or methyl,

4-[(thien-2-yl)methyl]-imidazole analgesics

This invention relates to new heterocyclic derivatives of guanidine and more particularly to such derivatives which have hypoglycemic activity, their methods of use for treating hyperglycemia and novel intermediate compounds for their preparation.

Guanidine derivatives

Guanidine derivatives, compositions and use

Novel hexahydro-2H-indeno[1,2-c]pyridines and their pharmaceutically acceptable acid addition salts having useful antipsychotic properties.

Antipsychotic hexahydro-2H-indeno[1,2-c]pyridine derivatives

Ureas of the formula (I): ##STR1## where R.sup.1 =alkoxy or alkylthio; R.sup.2 =alkyl; and Ar=substituted or unsubstituted phenyl, useful as anxiolytic agents as well as intermediates useful in the synthesis.

Anxiolytic 4,5-dihydro-4-oxo-1H-imidazol-2-yl urea derivatives

N-aryl-N'-(2-thiazolidinylidene)urea compounds of Formula II ##STR1## wherein: R is CH.sub.3, C.sub.2 H.sub.5, or H;

Anticonvulsant N-aryl-N'-(2-thiazolidinylidene)ureas

N-(substituted phenyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)ureas and pharmaceutically-acceptable salts thereof are disclosed to be useful in relieving the symptoms associated with irritable bowel syndrome, and as anti-diarrheal agents.

N-aryl-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)ureas for intestinal

5-Membered, 6-membered and 7-membered heterocyclic derivatives of guanidine having hypoglycemic activity.

Heterocyclic derivatives of guanidine

N-aryl-N'-(3-methyl or ethyl-4-oxothiazolidinylidene)urea compounds of Formula I ##STR1## wherein: R is CH.sub.3, C.sub.2 H.sub.5 ;

N-Aryl-N'-(3-methyl or ethyl-4-oxothiazolidinylidene)ureas useful for

N-(Substituted phenyl)-N'-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl)ureas, and pharmaceutically-acceptable salts thereof, are disclosed, as are compositions containing said ureas in a pharmaceutically-acceptable carrier, to have antihypertensive activity and to be useful in a method of reducing arterial pressure in hypertensive subjects.

N-Aryl-N-(4,5,6,7-tetrahydro-1H-1,3, diazepin-2-yl)ureas as

(1-Methyl-2-pyridinylidene) and (1-methyl-2-quinolinylidene) derivatives of guanidine having hypoglycemic activity.

(1-Methyl-2-quinolinylidene) derivatives of guanidine

N-(Mono- and (di-substituted phenyl)-N'-(2-imidazolidinylidene)urea compounds and acid addition salts thereof are taught, which are useful as antihypertensive agents.

N-(Substituted phenyl)-N'-(2-imidazolidinylidene)ureas

A process for controlling hypertension employing N-(substituted-phenyl)-N'-(1,4,5,6-tetrahydroprimidin-2-yl)ureas, and pharmaceutical compositions containing said ureas is described.

Growing community of inventors

Ambler, PA, United States of America

Chris R Rasmussen