University of Utah Research Foundation

American Cyanamid Company

Chris M Ireland

Robert M Kramer

Craig R Fairchild

John Alan Maschek

Derek C Radisky

Louis R Barrows

Ryan Van Wagoner

Vincente Planelles

Brent R Copp

Mary Kay Harper-Ireland

Annette Fernandez

Alberto Bosque-Pardos

In one aspect, the invention relates to triazol-1-ol compounds, analogs thereof, compositions comprising same, and methods of using same, alone or in combination with other agents, to reactivate latent retroviruses, and more particularly to reactivate latent HIV-1. Such compounds, compositions, and methods can be used, for example, in connection with diagnosing and/or treating a retrovirus, and more specifically HIV-1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Trizol-1-OL analogs anti-retroviral latency drugs

A purified bicyclic depsipeptide, vitilevuamide, from the ascidians Didemnum cuculliferum and Polysyncraton lithostrotum is disclosed. Vitilevuamide has antitumor activity as demonstrated by standard in vitro and in vivo assays. An anticancer composition is also disclosed, comprising an effective amount of vitilevuamide and an inert carrier. A method of treating cancer is also disclosed, comprising administering an anticancer composition comprising an effective amount of vitilevuamide and an inert carrier.

Cyclic peptide antitumor agent from an ascidian

Naamidine A isolated from marine sponges is found to be selective in inhibiting the growth of tumor cells which are dependent upon epidermal growth factor for their growth, while showing acceptably low general cytotoxicity. Such selectivity was established through in vitro and in vivo comparative testing using tumor cells which over express EGF receptor cites. The in vivo tests used nude athymic mice that were implanted with squamous cells carcinoma.

Naamidine A extracted from sea sponges and methods for its use as an

The invention discloses certain antitumor pyrrolo[4,3,2-de]quinolin-8(1H)-ones isolated from the Fijian marine sponge Z. cf. marsailis and structurally modified compounds thereof and pharmaceutical compositions.

Antineoplastic pyrrolo[4,3,2-de]quinolin-8(1H)-ones

Cytotoxic, antifungal macrolides identified as a patellazoles having a pendant thiazole-epoxy group have been derived from a Lissoclinum patella located in the Fiji Islands.

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Sandy, UT, United States of America

Chris M Ireland