Flodesign Sonics, Inc.

Chris Leidel

Bart Lipkens

Louis Masi

Thomas J Kennedy, Iii

Stanley J Kowalski, Iii

Walter M Presz, Jr

Jason Dionne

Kedar C Chitale

Brian Dutra

Rudolf Gilmanshin

Thomas Joseph Kennedy

Goutam Ghoshal

Iii Thomas J Kennedy

Iii Stanley Kowalski

Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.

Therapeutic cell washing, concentration, and separation utilizing acoustophoresis

A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. The nutrient fluid stream dislodges some cells from the cell culture, which can then be recovered for cell therapy applications. The cell culture continues to expand and reproduce, permitting continuous recovery of cells from the bioreactor.

Acoustic bioreactor processes

A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.

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Somerville, MA, United States of America

Chris Leidel