Merck Sharp + Dohme Corp.

Chris King

Nicholas D Smith

Jean-Michel Andre Vernier

Joseph E Payne

Dehua Huang

Brian Walter Eastman

Thomas Jon Seiders

Jeffrey Roger Roppe

Jeannie M Arruda

Bowei Wang

Nicholas David Cosford

Steve Fong Poon

Xiumin Zhao

Nicholas D Cosford

The identification of a unique series of compounds which possesses special advantages in terms of drug-like properties due to their possessing advantageous properties in terms of potency and/or pharmacokinetic and/or selectivity and/or in vivo receptor occupancy properties. Specifically, the selection of a 1,3-thiazol-2-yl ring member linked by an ethynylene to the 3 position of a pyridyl ring or the 5 position of a pyrimidinyl ring, wherein the ring is substituted with selected substituents, results in a compound having superior drug-like properties. The invention includes pharmaceutically acceptable salt forms of these heterocyclic compounds, in particular chloride salts and trifluoroacetate salts.

Thiazolyl mGluR5 antagonists and methods for their use

Thiazolyl mglur5 antagonists and methods for their use

Growing community of inventors

Carlsbad, CA, United States of America

Chris King