Merck Sharp + Dohme Corp.

Nicox S.a.

Chris Franklin

Amjad Ali

Michael Man-Chu Lo

Iyassu Sebhat

Nicoletta Almirante

Silvia Stefanini

Ravi P Nargund

Ennio Ongini

Laura Storoni

Stefano Biondi

Iyassu K Sebhat

A compound having the structureR&#x2014;Y  

Angiotensin II receptor antagonists

A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is -Y-Y-Y-Y-Y-; Yis C(RR); Ris selected from the group consisting of hydrogen and Calkyl; Ris selected from the group consisting of hydrogen, Calkyl, and &#x2014;OC(O)Calkyl; Yis O or CH; Yis C(O) or CH; Yis O or CH; Yis &#x2014;(CH)&#x2014;(X)&#x2014;(CH)&#x2014; or is absent; X is &#x2014;O&#x2014; or &#x2014;CRR&#x2014;; and Rand Rare independently selected from the group consisting of hydrogen and C-Calkyl; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

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Keasbey, NJ, United States of America

Chris Franklin