Case Western Reserve University

Chris Flask

Mark A Griswold

Jeffrey L Duerk

Jonathan S Lewin

Susann Brady-Kalnay

David L Wilson

Nicole F Steinmetz

Vikas Gulani

Dan Ma

Jinming Gao

Daniel Robert Elgort

Yun Jiang

Christian N Anderson

Eddy Y Wong

Claudia M Hillenbrand

Brent Weinberg

Guo-Qiang Zhang

Adam D Troy

Xin Yu

Remo Sebastian Wolfgang Mueller

Jacek Szymanski

Hua Ai

Xintao Shuai

Raymond F Muzic, Jr

Lan Lu

Ying Gao

The present disclosure provides a method of DDCE-MRF. The method can include: a) introducing two or more contrast agents to a region of interest (ROI) of a subject, the two or more contrast agents having different relaxivities; b) measuring a T1 relaxation time and a T2 relaxation time for locations within the ROI using magnetic resonance fingerprinting (MRF); c) determining, using equations that relate the different relaxivities, the T1 relaxation time, the T2 relaxation time, and concentrations of the two or more contrast agents, the concentrations of the two or more contrast agents for each of the locations within the ROI; and d) producing an image depicting the ROI based, at least in part, on the concentrations of the two or more contrast agents.

System and method for dynamic multiple contrast enhanced, magnetic resonance fingerprinting (DMCE-MRF)

A system and method is provided for operating a high-field magnetic resonance (MR) system includes performing a series of data acquisition modules without respiratory gating. Each data acquisition module is formed of a steady-state free precession pulse sequence. Performing the series of data acquisition modules includes varying at least one of an amplitude of an excitation pulse or a repetition time of the steady-state free precession pulse sequence between adjacent data acquisition modules in the series of data acquisition modules to acquire a series of MR data with random or pseudo-random imaging acquisition parameters. The series of MR data is compared to a dictionary of signal evolution profiles to determine a match between the series of MR data with at least one signal evolution profile in the dictionary indicating at least one quantitative parameter in the subject.

System and method for magnetic resonance fingerprinting at high field strengths

A multi-modality, multi-resource, information integration environment system is disclosed that comprises: (a) at least one computer readable medium capable of securely storing and archiving system data; (b) at least one computer system, or program thereon, designed to permit and facilitate web-based access of the at least one computer readable medium containing the secured and archived system data; (c) at least one computer system, or program thereon, designed to permit and facilitate resource scheduling or management; (d) at least one computer system, or program thereon, designed to monitor the overall resource usage of a core facility; and (e) at least one computer system, or program thereon, designed to track regulatory and operational qualifications.

Multi-modality, multi-resource, information integration environment

The invention relates to micelles that are elaborated with functionality useful for imaging and/or selectively targeting tissue, e.g., in the delivery of hydrophobic agents.

Dual function polymer micelles

A probe suitable for attachment to, or incorporation in, a medical interventional device, such as a catheter, and which may be employed for tracking, imaging, or both, includes a first material having an MR resonance frequency distinct from a resonance frequency of a second material adjacent to the first material. The probe may include one or more coils, or it may be wireless, that is, it may have no coils. Some probe configurations are directed at tracking or imaging of vascular vessels or tissue, and configurations allow both tracking and imaging.

MRI probe designs for minimally invasive intravascular tracking and imaging applications

Growing community of inventors

Avon Lake, OH, United States of America

Chris Flask