University of Texas System

Dispersol Technologies, LLC

Integrico Composites, Inc.

Austinpx, LLC

Little, David

Chris Brough

Robert O Williams, Iii

Dave A Miller

James C DiNunzio

James William McGinity

David Rice

James W Mcginity

Ryan Nielson

Gershon Yaniv

John Taylor

David Little

Elmer Good

Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Thermo-kinetic mixing for pharmaceutical applications

The present disclosure provides for a first embodiment, where, a first, lower shaft speed mixing of the component combination takes place in a thermokinetic mixer, where monitoring of the batch by temperature rate increase determination results in a determination that a substantial portion of desired thermokinetic mixing has occurred, whereafter a different shaft speed is used to complete the desired thermokinetic mixing of the component combination.

Direct probe sensed temperature method for speed change for heat sensitive portions of a thermokinetically melt blended batch

The present disclosure is directed to compositions and methods for making a pharmaceutical composition by thermokinetic compounding, wherein the compositions include one or more thermolabile components, for example one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients. The methods comprise thermokinetic processing of the thermolabile components into a composite by blending certain thermolabile components in a thermokinetic mixer using multiple speeds during a single, rotationally continuous operation. The composite can be further processed into pharmaceutical compositions by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Multiple speed process for preserving heat sensitive portions of a thermokinetically melt blended batch

A composite load bearing member is provided comprising an elongated inner structural member and a thick polymeric composite outer member. An apparatus for producing the composite load bearing member is provided including devices for suspending the inner structural member within a mold cavity prior to and during injection of the polymeric composite outer member. A method of using the apparatus to produce the composite load bearing member is provided.

Composite load bearing structure

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Austin, TX, United States of America

Chris Brough