Millennium Pharmaceuticals Limited

Takeda Pharmaceutical Company Limited

Chris Blackburn

Stephen G Stroud

Paul E Fleming

Tricia J Vos

Francois Soucy

He Xu

Gang Li

Yongbo Hu

Kenneth M Gigstad

Courtney A Cullis

Jeffrey P Ciavarri

Yingchun Ye

Indu T Bharathan

Michael D Sintchak

Mario Girard

Krista E Gipson

Jouhara Chouitar

Mansoureh Rezaei

Natalie D'Amore

Janice Lee

Tzu-Tshin Wong

Tianlin Xu

George A Sachs

Barry Berkowitz

The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R, R, R, R, R, L, L, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

Heteroaryls and uses thereof

The present invention provides a compound of formula I: 

Methods for controlling growth of gram negative bacteria, such as,which are agents associated with disorders of the gastrointestinal tract of a mammal are described. They include administering a therapeutically effective amount of a polyether ionophore antibiotic to a mammal, such that growth of gram negative bacteria which are agents associated with disorders of the gastrointestinal tract of a mammal is controlled. Packaged pharmaceutical compositions for controlling gram negative bacteria are also described. The packaged compositions include a container holding a therapeutically effective amount of a pharmaceutical composition for controlling gram negative bacteria which are agents associated with disorders of the gastrointestinal tract of a mammal and instructions for using the pharmaceutical composition for control of the gram negative bacteria, such that growth of gram negative bacteria which are agents associated with disorders of the gastrointestinal tract of a mammal is controlled. The pharmaceutical composition includes at least one polyether ionophore antibiotic or a bicyclic spiroether.

Methods for controlling gram negative bacteria in mammals with bicyclo spiroether compounds

Methods for controlling growth of gram negative bacteria, such as Helicobacter pylori, which are agents associated with disorders of the gastrointestinal tract of a mammal are described. They include administering a therapeutically effective amount of a polyether ionophore antibiotic to a mammal, such that growth of gram negative bacteria which are agents associated with disorders of the gastrointestinal tract of a mammal is controlled. Packaged pharmaceutical compositions for controlling gram negative bacteria are also described. The packaged compositions include a container holding a therapeutically effective amount of a pharmaceutical composition for controlling gram negative bacteria which are agents associated with disorders of the gastrointestinal tract of a mammal and instructions for using the pharmaceutical composition for control of the gram negative bacteria, such that growth of gram negative bacteria which are agents associated with disorders of the gastrointestinal tract of a mammal is controlled. The pharmaceutical composition includes at least one polyether ionophore antibiotic or a bicyclic spiroether.

Methods for controlling gram negative bacteria in mammals

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Natick, MA, United States of America

Chris Blackburn