Dartmouth College

Insmed Incorporated

Stealth Biologics, LLC

Chris Bailey-Kellogg

Karl E Griswold

Yoonjoo Choi

Hongliang Zhao

Deeptak Verma

Kristina Blazanovic

Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.

Deimmunized lysostaphin and methods of use

Provided are variants of a chimeric anti-EGFR antibody. In various embodiments, the variants exhibit substantially improved thermostabilities and/or substantially higher levels of humanness, while retaining binding affinity near the parental level. The consistently high quality of the turnkey CoDAH designs, over a whole panel of variants, suggests that a computationally-directed approach encapsulates key determinants of antibody structure and function.

Antibodies and methods of making same

Growing community of inventors

Strafford, VT, United States of America

Chris Bailey-Kellogg