Syntex (u.s.a.) Inc.

Roche Palo Alto LLC

Agouron Pharmaceuticals, Inc.

Other

F. Hoffmann-la Roche Ag

Chris Allen Broka

Jeffrey Allen Campbell

Ronald Charles Hawley

Jian Jeffrey Chen

Michael Patrick Dillon

Arlindo Lucas Castelhano

Alam Jahangir

David Scott Carter

Robert Than Hendricks

Daniel Warren Parish

Keith Adrian Murray Walker

Michael J Melnick

Keith Adrian Walker

Clara Jeou Jen Lin

Nancy Delaet

Sharon Marie Dankwardt

Leslie Ann Robinson

Roland Joseph Billledeau

David Bernard Smith

Amy Geraldine Moore

Kevin L McLaren

Anthony P D W Ford

Woongki Kim

Steven Lee Bender

Lawrence Emerson Fisher

Keshab Sarma

Clara Jeou Lin

Anthony Pdw Ford

Anthony PDW Ford

Compounds and methods for treating diseases mediated by a P2Xand/or a P2Xreceptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof,wherein D, X, Y, R, R, R, R, R, R, Rand Rare as defined herein.

[object Object]

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, Ris optionally substituted phenyl or optionally substituted pyridinyl, and R, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2Xand/or a P2Xreceptor antagonists and methods of making the compounds.

Pyridinyl amides as P2X3  and P2X2/3 inhibitors

Compounds and methods for treating diseases mediated by a P2Xand/or a P2Xreceptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof,

Methods for treating respiratory and gastrointestinal diseases mediated by a P2Xand/or a P2Xreceptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof,wherein D, X, Y, R, R, R, R, R, R, Rand Rare as defined herein.

Methods for treating respiratory and gastrointestinal diseases mediated by a P2Xand/or a P2Xreceptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof,

This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a &#x2014;CH&#x2014;, &#x2014;O&#x2014;, &#x2014;S&#x2014;, or &#x2014;S(O)&#x2014;; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents

Indole derivatives as anti-inflammatory agents

This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a CH, CH(OH), C(O), C&#x2550;NOR, NR, O, S, S(O), or S(O), and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.

Quinoline derivatives as anti-inflammatory agents

This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a CH, CH(OH), C(O), C&#x2550;NOR, NR, O, S, S(O), or S(O), and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents

This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I:wherein A is a &#x2014;CH&#x2014;, &#x2014;O&#x2014;, &#x2014;S&#x2014;, or &#x2014;S(O)&#x2014;; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.

This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

Sulfonamide hydroxamates

Sulfonamide compounds

Growing community of inventors

Foster City, CA, United States of America

Chris Allen Broka